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7WIY

Cryo-EM structure of human TPH2 tetramer

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0004510molecular_functiontryptophan 5-monooxygenase activity
A0005506molecular_functioniron ion binding
A0005829cellular_componentcytosol
A0009072biological_processaromatic amino acid metabolic process
A0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
A0042427biological_processserotonin biosynthetic process
A0043005cellular_componentneuron projection
A0046872molecular_functionmetal ion binding
B0004497molecular_functionmonooxygenase activity
B0004510molecular_functiontryptophan 5-monooxygenase activity
B0005506molecular_functioniron ion binding
B0005829cellular_componentcytosol
B0009072biological_processaromatic amino acid metabolic process
B0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B0042427biological_processserotonin biosynthetic process
B0043005cellular_componentneuron projection
B0046872molecular_functionmetal ion binding
C0004497molecular_functionmonooxygenase activity
C0004510molecular_functiontryptophan 5-monooxygenase activity
C0005506molecular_functioniron ion binding
C0005829cellular_componentcytosol
C0009072biological_processaromatic amino acid metabolic process
C0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
C0042427biological_processserotonin biosynthetic process
C0043005cellular_componentneuron projection
C0046872molecular_functionmetal ion binding
D0004497molecular_functionmonooxygenase activity
D0004510molecular_functiontryptophan 5-monooxygenase activity
D0005506molecular_functioniron ion binding
D0005829cellular_componentcytosol
D0009072biological_processaromatic amino acid metabolic process
D0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
D0042427biological_processserotonin biosynthetic process
D0043005cellular_componentneuron projection
D0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00367
Number of Residues12
DetailsBH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDtcHELLGHVP
ChainResidueDetails
BPRO314-PRO325

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BHIS318
AHIS318
AHIS323
AGLU363
BHIS323
BGLU363
CHIS318
CHIS323
CGLU363
DHIS318
DHIS323
DGLU363

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8CGU9
ChainResidueDetails
BSER19
CSER19
DSER19
ASER19

223790

PDB entries from 2024-08-14

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