7WIY

Cryo-EM structure of human TPH2 tetramer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0004510	molecular_function	tryptophan 5-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005829	cellular_component	cytosol
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
A	0042427	biological_process	serotonin biosynthetic process
A	0043005	cellular_component	neuron projection
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0004510	molecular_function	tryptophan 5-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005829	cellular_component	cytosol
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B	0042427	biological_process	serotonin biosynthetic process
B	0043005	cellular_component	neuron projection
B	0046872	molecular_function	metal ion binding
C	0004497	molecular_function	monooxygenase activity
C	0004510	molecular_function	tryptophan 5-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005829	cellular_component	cytosol
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
C	0042427	biological_process	serotonin biosynthetic process
C	0043005	cellular_component	neuron projection
C	0046872	molecular_function	metal ion binding
D	0004497	molecular_function	monooxygenase activity
D	0004510	molecular_function	tryptophan 5-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005829	cellular_component	cytosol
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
D	0042427	biological_process	serotonin biosynthetic process
D	0043005	cellular_component	neuron projection
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00367
Number of Residues	12
Details	BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDtcHELLGHVP

Chain	Residue	Details
B	PRO314-PRO325

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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