7W7O
The crystal structure of human Calpain-1 protease core in complex with 14a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calpain-1 catalytic subunit | polymer | 334 | 37715.5 | 1 | UniProt (P07384) Pfam (PF00648) | Homo sapiens (human) | Calcium-activated neutral proteinase 1,CANP 1,Calpain mu-type,Calpain-1 large subunit,Cell proliferation-inducing gene 30 protein,Micromolar-calpain,muCANP |
| 2 | B (A) | N-[(2S)-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2S,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide | non-polymer | 614.7 | 1 | Chemie (06Q) | |||
| 3 | C (A) | HYDROSULFURIC ACID | non-polymer | 34.1 | 1 | Chemie (H2S) PubChem (5362487) PubChem (402) | |||
| 4 | D, E (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 5 | F (A) | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37715.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 728.9 | |
| All* | Total formula weight | 38444.4 |
