7W7O

The crystal structure of human Calpain-1 protease core in complex with 14a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004198	molecular_function	calcium-dependent cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaLGDCWLlAA

Chain	Residue	Details
A	GLN109-ALA120

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	299
Details	Domain: {"description":"Calpain catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00239","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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