7W02
Cryo-EM structure of ATP-bound ABCA3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phospholipid-transporting ATPase ABCA3 | polymer | 1748 | 196511.7 | 1 | UniProt (Q99758) Pfam (PF12698) Pfam (PF00005) Pfam (PF23321) | Homo sapiens (Human) | ABC-C transporter,ATP-binding cassette sub-family A member 3,ATP-binding cassette transporter 3,ATP-binding cassette 3,Xenobiotic-transporting ATPase ABCA3 |
| 2 | B, C (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 1 - 1704 (UniProt: Q99758)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Ala -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Tyr -17 | - | expression tag |
| Lys -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Lys -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Gln 690 | Glu 690 | engineered mutation |
| Gln 1540 | Glu 1540 | engineered mutation |
| Leu 1705 | - | expression tag |
| Glu 1706 | - | expression tag |
| Gly 1707 | - | expression tag |
| Ser 1708 | - | expression tag |
| Asp 1709 | - | expression tag |
| Glu 1710 | - | expression tag |
| Val 1711 | - | expression tag |
| Asp 1712 | - | expression tag |
| Ala 1713 | - | expression tag |
| Val 1714 | - | expression tag |
| Glu 1715 | - | expression tag |
| Gly 1716 | - | expression tag |
| Ser 1717 | - | expression tag |
| His 1718 | - | expression tag |
| His 1719 | - | expression tag |
| His 1720 | - | expression tag |
| His 1721 | - | expression tag |
| His 1722 | - | expression tag |
| His 1723 | - | expression tag |
| His 1724 | - | expression tag |
| His 1725 | - | expression tag |
| His 1726 | - | expression tag |
| His 1727 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 196511.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1505.4 | |
| All* | Total formula weight | 198017.1 |
