7W02

Cryo-EM structure of ATP-bound ABCA3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005319	molecular_function	lipid transporter activity
A	0005524	molecular_function	ATP binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005770	cellular_component	late endosome
A	0005886	cellular_component	plasma membrane
A	0006855	biological_process	xenobiotic transmembrane transport
A	0006869	biological_process	lipid transport
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0010875	biological_process	positive regulation of cholesterol efflux
A	0012505	cellular_component	endomembrane system
A	0015914	biological_process	phospholipid transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0030324	biological_process	lung development
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031340	biological_process	positive regulation of vesicle fusion
A	0031410	cellular_component	cytoplasmic vesicle
A	0031902	cellular_component	late endosome membrane
A	0032368	biological_process	regulation of lipid transport
A	0032464	biological_process	positive regulation of protein homooligomerization
A	0032585	cellular_component	multivesicular body membrane
A	0034204	biological_process	lipid translocation
A	0042599	cellular_component	lamellar body
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0043129	biological_process	surfactant homeostasis
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046618	biological_process	xenobiotic export from cell
A	0046890	biological_process	regulation of lipid biosynthetic process
A	0051384	biological_process	response to glucocorticoid
A	0055085	biological_process	transmembrane transport
A	0055091	biological_process	phospholipid homeostasis
A	0070925	biological_process	organelle assembly
A	0097208	cellular_component	alveolar lamellar body
A	0097232	cellular_component	lamellar body membrane
A	0097233	cellular_component	alveolar lamellar body membrane
A	0120009	biological_process	intermembrane lipid transfer
A	0120019	molecular_function	phosphatidylcholine transfer activity
A	0140326	molecular_function	ATPase-coupled intramembrane lipid transporter activity
A	0140345	molecular_function	phosphatidylcholine flippase activity
A	0140359	molecular_function	ABC-type transporter activity
A	0150172	biological_process	regulation of phosphatidylcholine metabolic process
A	1902995	biological_process	positive regulation of phospholipid efflux
A	2001140	biological_process	positive regulation of phospholipid transport

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGMRRKLSIGIAL

Chain	Residue	Details
A	LEU665-LEU679

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	282
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	233
Details	Domain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24142515","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---