7VPQ
Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E | Aminopeptidase N | polymer | 909 | 103966.5 | 3 | UniProt (P15144) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB | Homo sapiens (Human) | AP-N,hAPN,Alanyl aminopeptidase,Aminopeptidase M,AP-M,Microsomal aminopeptidase,Myeloid plasma membrane glycoprotein CD13,gp150 |
2 | B, D, F | Spike protein | polymer | 127 | 14326.2 | 3 | UniProt (A0A4P8D758) Pfam (PF01600) In PDB | Porcine deltacoronavirus | |
3 | G, H, J, K, L | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
4 | I | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G79924RM) | |||
5 | E, A, C | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
6 | D, E, F, A, B... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) | |||
7 | C, E, A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) |
Sequence modifications
A, C, E: 62 - 963 (UniProt: P15144)
B, D, F: 300 - 419 (UniProt: A0A4P8D758)
PDB | External Database | Details |
---|---|---|
Gly 964 | - | expression tag |
His 965 | - | expression tag |
His 966 | - | expression tag |
His 967 | - | expression tag |
His 968 | - | expression tag |
His 969 | - | expression tag |
His 970 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 420 | - | expression tag |
His 421 | - | expression tag |
His 422 | - | expression tag |
His 423 | - | expression tag |
His 424 | - | expression tag |
His 425 | - | expression tag |
His 426 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 354878.1 | |
Branched | Number of molecules | 6 |
Total formula weight | 2546.4 | |
Non-Polymers* | Number of molecules | 24 |
Total formula weight | 4454.3 | |
All* | Total formula weight | 361878.8 |