7VPQ

Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (A, C, E)	Aminopeptidase N	polymer	909	103966.5	3	UniProt (P15144) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Homo sapiens (Human)	AP-N,hAPN,Alanyl aminopeptidase,Aminopeptidase M,AP-M,Microsomal aminopeptidase,Myeloid plasma membrane glycoprotein CD13,gp150
2	B, D, F (B, D, F)	Spike protein	polymer	127	14326.2	3	UniProt (A0A4P8D758) Pfam (PF01600)	Porcine deltacoronavirus
3	G, H, J, K, L (G, H, J, K, L)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
4	I (I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G79924RM)
5	CA, M, U (E, A, C)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
6	BA, DA, EA, FA, GA... (D, E, F, A, B...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	18	Chemie (NAG)
7	AA, IA, S (C, E, A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)

Sequence modifications

A, C, E: 62 - 963 (UniProt: P15144)

PDB	External Database	Details
Gly 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag
His 968	-	expression tag
His 969	-	expression tag
His 970	-	expression tag

B, D, F: 300 - 419 (UniProt: A0A4P8D758)

PDB	External Database	Details
Gly 420	-	expression tag
His 421	-	expression tag
His 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	354878.1
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	24
	Total formula weight	4454.3
All*	Total formula weight	361878.8

*Water molecules are not included.