7VPP

Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Aminopeptidase	polymer	911	103803.6	2	UniProt (K7GMF9) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) UniProt (by SIFTS) (P15145) In PDB	Sus scrofa (Pig)
2	B	Spike protein	polymer	127	14326.2	1	UniProt (A0A4P8D758) Pfam (PF01600) In PDB	Porcine deltacoronavirus
3	D, E, F, G, H...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	9	In PDB GlyTouCan (G42666HT)
4	L	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G79924RM)
5	A, C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	A, C	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
7	A, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
8		water	water		18.0	35	Chemie (HOH)

Sequence modifications

A, C: 58 - 961 (UniProt: K7GMF9)

PDB	External Database	Details
Gly 962	-	expression tag
His 963	-	expression tag
His 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag
His 968	-	expression tag

B: 300 - 419 (UniProt: A0A4P8D758)

PDB	External Database	Details
Gly 420	-	expression tag
His 421	-	expression tag
His 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	221933.3
Branched	Number of molecules	10
	Total formula weight	4244.0
Non-Polymers*	Number of molecules	12
	Total formula weight	1697.3
All*	Total formula weight	227874.6

*Water molecules are not included.