7VPP
Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001525 | biological_process | angiogenesis |
A | 0001618 | molecular_function | virus receptor activity |
A | 0004177 | molecular_function | aminopeptidase activity |
A | 0005615 | cellular_component | extracellular space |
A | 0005737 | cellular_component | cytoplasm |
A | 0005886 | cellular_component | plasma membrane |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0030154 | biological_process | cell differentiation |
A | 0042277 | molecular_function | peptide binding |
A | 0043171 | biological_process | peptide catabolic process |
A | 0046718 | biological_process | symbiont entry into host cell |
A | 0046872 | molecular_function | metal ion binding |
A | 0070006 | molecular_function | metalloaminopeptidase activity |
B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
C | 0001525 | biological_process | angiogenesis |
C | 0001618 | molecular_function | virus receptor activity |
C | 0004177 | molecular_function | aminopeptidase activity |
C | 0005615 | cellular_component | extracellular space |
C | 0005737 | cellular_component | cytoplasm |
C | 0005886 | cellular_component | plasma membrane |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0030154 | biological_process | cell differentiation |
C | 0042277 | molecular_function | peptide binding |
C | 0043171 | biological_process | peptide catabolic process |
C | 0046718 | biological_process | symbiont entry into host cell |
C | 0046872 | molecular_function | metal ion binding |
C | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHELAHQW |
Chain | Residue | Details |
A | VAL380-TRP389 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095 |
Chain | Residue | Details |
A | GLU384 | |
C | GLU384 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | GLY347 | |
C | GLY347 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22876187, ECO:0007744|PDB:4F5C |
Chain | Residue | Details |
A | HIS383 | |
A | HIS387 | |
A | GLU406 | |
C | HIS383 | |
C | HIS387 | |
C | GLU406 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | TYR472 | |
C | TYR472 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Sulfotyrosine => ECO:0000255 |
Chain | Residue | Details |
A | TYR171 | |
C | TYR171 |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22876187, ECO:0007744|PDB:4F5C |
Chain | Residue | Details |
A | ASN82 | |
A | ASN736 | |
C | ASN82 | |
C | ASN124 | |
C | ASN229 | |
C | ASN237 | |
C | ASN314 | |
C | ASN328 | |
C | ASN506 | |
C | ASN622 | |
C | ASN646 | |
A | ASN124 | |
C | ASN736 | |
A | ASN229 | |
A | ASN237 | |
A | ASN314 | |
A | ASN328 | |
A | ASN506 | |
A | ASN622 | |
A | ASN646 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN258 | |
A | ASN286 | |
A | ASN556 | |
A | ASN569 | |
C | ASN258 | |
C | ASN286 | |
C | ASN556 | |
C | ASN569 |