7VNR

Structure of human KCNQ4-ML213 complex in digitonin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, C, E, G)	Potassium voltage-gated channel subfamily KQT member 4,Maltodextrin-binding protein	polymer	1049	116541.4	4	UniProt (P56696) UniProt (A0A140NCD0) Pfam (PF00520) Pfam (PF07885) Pfam (PF03520)	Homo sapiens (Human)	KQT-like 4,Potassium channel subunit alpha KvLQT4,Voltage-gated potassium channel subunit Kv7.4
2	E, F, G, H (B, D, F, H)	Calmodulin-3	polymer	149	16852.5	4	UniProt (P0DP25) Pfam (PF13499)	Homo sapiens (Human)
3	I, M, N, O (A, C, E, G)	(1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid	non-polymer		257.4	4	Chemie (7YV)
4	J, K, L (A)	POTASSIUM ION	non-polymer		39.1	3	Chemie (K)

Sequence modifications

A, C, E, G: 2 - 650 (UniProt: P56696)

PDB	External Database	Details
Met -7	-	initiating methionine
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag
Leu 651	-	linker
Glu 652	-	linker
Val 653	-	linker
Leu 654	-	linker
Phe 655	-	linker
Gln 656	-	linker
Gly 657	-	linker
Pro 658	-	linker
Met 659	-	linker

A, C, E, G: 660 - 1026 (UniProt: A0A140NCD0)

PDB	External Database	Details
Asn 1027	-	expression tag
Ala 1028	-	expression tag
Ala 1029	-	expression tag
Ala 1030	-	expression tag
Glu 1031	-	expression tag
His 1032	-	expression tag
His 1033	-	expression tag
His 1034	-	expression tag
His 1035	-	expression tag
His 1036	-	expression tag
His 1037	-	expression tag
His 1038	-	expression tag
His 1039	-	expression tag
His 1040	-	expression tag
His 1041	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	533575.7
Non-Polymers*	Number of molecules	7
	Total formula weight	1146.8
All*	Total formula weight	534722.5

*Water molecules are not included.