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7VNR

Structure of human KCNQ4-ML213 complex in digitonin

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0007605biological_processsensory perception of sound
A0008076cellular_componentvoltage-gated potassium channel complex
A0008643biological_processcarbohydrate transport
A0009925cellular_componentbasal plasma membrane
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0042472biological_processinner ear morphogenesis
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
B0000086biological_processG2/M transition of mitotic cell cycle
B0000922cellular_componentspindle pole
B0002027biological_processregulation of heart rate
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0007186biological_processG protein-coupled receptor signaling pathway
B0008076cellular_componentvoltage-gated potassium channel complex
B0008179molecular_functionadenylate cyclase binding
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030017cellular_componentsarcomere
B0030234molecular_functionenzyme regulator activity
B0031432molecular_functiontitin binding
B0031954biological_processpositive regulation of protein autophosphorylation
B0031982cellular_componentvesicle
B0032465biological_processregulation of cytokinesis
B0032516biological_processpositive regulation of phosphoprotein phosphatase activity
B0032991cellular_componentprotein-containing complex
B0034704cellular_componentcalcium channel complex
B0035307biological_processpositive regulation of protein dephosphorylation
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050848biological_processregulation of calcium-mediated signaling
B0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0072542molecular_functionprotein phosphatase activator activity
B0097225cellular_componentsperm midpiece
B0098901biological_processregulation of cardiac muscle cell action potential
B1901842biological_processnegative regulation of high voltage-gated calcium channel activity
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B1902494cellular_componentcatalytic complex
B1905913biological_processnegative regulation of calcium ion export across plasma membrane
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0007605biological_processsensory perception of sound
C0008076cellular_componentvoltage-gated potassium channel complex
C0008643biological_processcarbohydrate transport
C0009925cellular_componentbasal plasma membrane
C0015144molecular_functioncarbohydrate transmembrane transporter activity
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0042472biological_processinner ear morphogenesis
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0002027biological_processregulation of heart rate
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0007186biological_processG protein-coupled receptor signaling pathway
D0008076cellular_componentvoltage-gated potassium channel complex
D0008179molecular_functionadenylate cyclase binding
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0016020cellular_componentmembrane
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030017cellular_componentsarcomere
D0030234molecular_functionenzyme regulator activity
D0031432molecular_functiontitin binding
D0031954biological_processpositive regulation of protein autophosphorylation
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032516biological_processpositive regulation of phosphoprotein phosphatase activity
D0032991cellular_componentprotein-containing complex
D0034704cellular_componentcalcium channel complex
D0035307biological_processpositive regulation of protein dephosphorylation
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050848biological_processregulation of calcium-mediated signaling
D0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0072542molecular_functionprotein phosphatase activator activity
D0097225cellular_componentsperm midpiece
D0098901biological_processregulation of cardiac muscle cell action potential
D1901842biological_processnegative regulation of high voltage-gated calcium channel activity
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
E0005216molecular_functionmonoatomic ion channel activity
E0005249molecular_functionvoltage-gated potassium channel activity
E0005267molecular_functionpotassium channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0007605biological_processsensory perception of sound
E0008076cellular_componentvoltage-gated potassium channel complex
E0008643biological_processcarbohydrate transport
E0009925cellular_componentbasal plasma membrane
E0015144molecular_functioncarbohydrate transmembrane transporter activity
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0042472biological_processinner ear morphogenesis
E0055085biological_processtransmembrane transport
E0071805biological_processpotassium ion transmembrane transport
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0008179molecular_functionadenylate cyclase binding
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0030234molecular_functionenzyme regulator activity
F0031432molecular_functiontitin binding
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
G0005216molecular_functionmonoatomic ion channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0005267molecular_functionpotassium channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0007605biological_processsensory perception of sound
G0008076cellular_componentvoltage-gated potassium channel complex
G0008643biological_processcarbohydrate transport
G0009925cellular_componentbasal plasma membrane
G0015144molecular_functioncarbohydrate transmembrane transporter activity
G0016020cellular_componentmembrane
G0034220biological_processmonoatomic ion transmembrane transport
G0034702cellular_componentmonoatomic ion channel complex
G0042472biological_processinner ear morphogenesis
G0055085biological_processtransmembrane transport
G0071805biological_processpotassium ion transmembrane transport
H0000086biological_processG2/M transition of mitotic cell cycle
H0000922cellular_componentspindle pole
H0002027biological_processregulation of heart rate
H0005509molecular_functioncalcium ion binding
H0005513biological_processdetection of calcium ion
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005819cellular_componentspindle
H0005856cellular_componentcytoskeleton
H0005876cellular_componentspindle microtubule
H0005886cellular_componentplasma membrane
H0007186biological_processG protein-coupled receptor signaling pathway
H0008076cellular_componentvoltage-gated potassium channel complex
H0008179molecular_functionadenylate cyclase binding
H0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
H0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
H0010856molecular_functionadenylate cyclase activator activity
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0030017cellular_componentsarcomere
H0030234molecular_functionenzyme regulator activity
H0031432molecular_functiontitin binding
H0031954biological_processpositive regulation of protein autophosphorylation
H0031982cellular_componentvesicle
H0032465biological_processregulation of cytokinesis
H0032516biological_processpositive regulation of phosphoprotein phosphatase activity
H0032991cellular_componentprotein-containing complex
H0034704cellular_componentcalcium channel complex
H0035307biological_processpositive regulation of protein dephosphorylation
H0043209cellular_componentmyelin sheath
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0044325molecular_functiontransmembrane transporter binding
H0046872molecular_functionmetal ion binding
H0048306molecular_functioncalcium-dependent protein binding
H0050848biological_processregulation of calcium-mediated signaling
H0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
H0051592biological_processresponse to calcium ion
H0055117biological_processregulation of cardiac muscle contraction
H0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
H0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
H0071902biological_processpositive regulation of protein serine/threonine kinase activity
H0072542molecular_functionprotein phosphatase activator activity
H0097225cellular_componentsperm midpiece
H0098901biological_processregulation of cardiac muscle cell action potential
H1901842biological_processnegative regulation of high voltage-gated calcium channel activity
H1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
H1902494cellular_componentcatalytic complex
H1905913biological_processnegative regulation of calcium ion export across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
BASP20-LEU32
BASP56-PHE68
BASP93-LEU105
BASP129-PHE141

site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO767-ASN784

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
AALA98-LEU118
BGLU67
BASP93
BASP95
BASN97
BTYR99
BGLU104
BASP129
BASP131
BASP133
BGLN135
CALA98-LEU118
BGLU140
DASP20
DASP22
DASP24
DTHR26
DGLU31
DASP56
DASP58
DASN60
DTHR62
EALA98-LEU118
DGLU67
DASP93
DASP95
DASN97
DTYR99
DGLU104
DASP129
DASP131
DASP133
DGLN135
GALA98-LEU118
DGLU140
FASP20
FASP22
FASP24
FTHR26
FGLU31
FASP56
FASP58
FASN60
FTHR62
BGLU31
FGLU67
FASP93
FASP95
FASN97
FTYR99
FGLU104
FASP129
FASP131
FASP133
FGLN135
BASP56
FGLU140
HASP20
HASP22
HASP24
HTHR26
HGLU31
HASP56
HASP58
HASN60
HTHR62
BASP58
HGLU67
HASP93
HASP95
HASN97
HTYR99
HGLU104
HASP129
HASP131
HASP133
HGLN135
BASN60
HGLU140
BTHR62

site_idSWS_FT_FI2
Number of Residues132
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ASER119-CYS131
EGLN194-SER201
EALA259-TYR270
ETHR293-GLY296
GSER119-CYS131
GGLN194-SER201
GALA259-TYR270
GTHR293-GLY296
AGLN194-SER201
AALA259-TYR270
ATHR293-GLY296
CSER119-CYS131
CGLN194-SER201
CALA259-TYR270
CTHR293-GLY296
ESER119-CYS131

site_idSWS_FT_FI3
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
ALEU132-TRP152
CLEU132-TRP152
ELEU132-TRP152
GLEU132-TRP152

site_idSWS_FT_FI4
Number of Residues124
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ASER153-LYS172
ALYS225-GLU237
CSER153-LYS172
CLYS225-GLU237
ESER153-LYS172
ELYS225-GLU237
GSER153-LYS172
GLYS225-GLU237

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
APRO173-THR193
CPRO173-THR193
EPRO173-THR193
GPRO173-THR193

site_idSWS_FT_FI6
Number of Residues88
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
AALA202-TRP224
CALA202-TRP224
EALA202-TRP224
GALA202-TRP224

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
ALEU238-LEU258
CLEU238-LEU258
ELEU238-LEU258
GLEU238-LEU258

site_idSWS_FT_FI8
Number of Residues84
DetailsINTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255
ChainResidueDetails
AALA271-HIS292
CALA271-HIS292
EALA271-HIS292
GALA271-HIS292

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
AARG297-ILE317
CARG297-ILE317
EARG297-ILE317
GARG297-ILE317

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
BLYS115
DLYS115
FLYS115
HLYS115

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
BTYR138
DTYR138
FTYR138
HTYR138

site_idSWS_FT_FI12
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
BLYS21
DLYS21
FLYS21
HLYS21

218853

PDB entries from 2024-04-24

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