7VI0
Crystal structure of EP300 HAT domain in complex with compound 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone acetyltransferase p300 | polymer | 454 | 52405.7 | 2 | UniProt (Q09472) Pfam (PF06001) Pfam (PF08214) | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300 |
| 2 | C, D, E, G, H... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 3 | F, J (A, B) | (4S)-N-(3H-indazol-4-yl)-3-[1-(4-methoxyphenyl)cyclopentyl]carbonyl-1,1-bis(oxidanylidene)-1,3-thiazolidine-4-carboxamide | non-polymer | 482.6 | 2 | Chemie (6YI) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 507 | Chemie (HOH) |
Sequence modifications
A, B: 1159 - 1519 (UniProt: Q09472)
A, B: 1581 - 1666 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Gly 1157 | - | expression tag |
| Pro 1158 | - | expression tag |
| Phe 1467 | Tyr 1467 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 1520 | - | linker |
| Gly 1521 | - | linker |
| Gly 1578 | - | linker |
| Ser 1579 | - | linker |
| Gly 1580 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 104811.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1357.6 | |
| All* | Total formula weight | 106169.0 |
