7VI0

Crystal structure of EP300 HAT domain in complex with compound 11

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0004402	molecular_function	histone acetyltransferase activity
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:24819397

Chain	Residue	Details
A	LEU1398
B	TRP1466
A	ARG1410
A	ILE1457
A	ARG1462
A	TRP1466
B	LEU1398
B	ARG1410
B	ILE1457
B	ARG1462

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:B2RWS6

Chain	Residue	Details
A	LYS1180
B	LYS1180

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17065153

Chain	Residue	Details
A	LYS1336
A	LYS1473
B	LYS1336
B	LYS1473

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546

Chain	Residue	Details
A	LYS1499
B	LYS1499

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1583
B	LYS1583

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