7UXD
Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy Zebularine.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA dC->dU-editing enzyme APOBEC-3G | polymer | 199 | 23120.1 | 1 | UniProt (Q9HC16) Pfam (PF05240) | Homo sapiens (human) | APOBEC-related cytidine deaminase,APOBEC-related protein,ARCD,APOBEC-related protein 9,ARP-9,CEM-15,CEM15,Deoxycytidine deaminase,A3G |
| 2 | B (B) | DNA (5'-D(*AP*AP*TP*CP*CP*(DDN)P*AP*AP*A)-3') | polymer | 9 | 2695.8 | 1 | synthetic construct | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A: 191 - 384 (UniProt: Q9HC16)
| PDB | External Database | Details |
|---|---|---|
| Gly 186 | - | expression tag |
| Pro 187 | - | expression tag |
| Leu 188 | - | expression tag |
| Gly 189 | - | expression tag |
| Ser 190 | - | expression tag |
| Ala 200 | Pro 200 | engineered mutation |
| Lys 234 | Leu 234 | engineered mutation |
| Ala 236 | Asn 236 | engineered mutation |
| Ala 243 | Cys 243 | engineered mutation |
| Lys 247 | Pro 247 | engineered mutation |
| Lys 310 | Phe 310 | engineered mutation |
| Lys 318 | Gln 318 | engineered mutation |
| Ala 321 | Cys 321 | engineered mutation |
| Ala 322 | Gln 322 | engineered mutation |
| Ala 356 | Cys 356 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25815.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 25881.3 |
