7UXD
Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy Zebularine.
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00903 |
| Number of Residues | 39 |
| Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElcFLdvipfwkldldqdyrvtcftsws..........PCfs......CaqeM |
| Chain | Residue | Details |
| A | HIS257-MET295 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 114 |
| Details | Domain: {"description":"CMP/dCMP-type deaminase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 127 |
| Details | Region: {"description":"Necessary for homooligomerization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37419875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8H0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J62","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKA and CAMK2","evidences":[{"source":"PubMed","id":"21659520","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253590","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253590","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
