7UV0
Structure of the sodium/iodide symporter (NIS) in complex with iodide and sodium
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/iodide cotransporter | polymer | 694 | 73914.4 | 1 | UniProt (Q63008) Pfam (PF00474) | Rattus norvegicus (Norway rat) | Na(+)/I(-) cotransporter,Sodium-iodide symporter,Na(+)/I(-) symporter,Solute carrier family 5 member 5 |
| 2 | B, C (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 3 | D (A) | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) | |||
| 4 | E (A) | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE | non-polymer | 705.0 | 1 | Chemie (3PH) |
Sequence modifications
A: 2 - 618 (UniProt: Q63008)
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | initiating methionine |
| Tyr -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Tyr -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Val -10 | - | expression tag |
| Pro -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Ala -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Gln 225 | Asn 225 | engineered mutation |
| Gln 485 | Asn 485 | engineered mutation |
| Gln 497 | Asn 497 | engineered mutation |
| Ser 619 | - | expression tag |
| Gly 620 | - | expression tag |
| Gly 621 | - | expression tag |
| Gly 622 | - | expression tag |
| Gly 623 | - | expression tag |
| Ala 624 | - | expression tag |
| Leu 625 | - | expression tag |
| Glu 626 | - | expression tag |
| Val 627 | - | expression tag |
| Leu 628 | - | expression tag |
| Phe 629 | - | expression tag |
| Gln 630 | - | expression tag |
| Gly 631 | - | expression tag |
| Pro 632 | - | expression tag |
| His 633 | - | expression tag |
| His 634 | - | expression tag |
| His 635 | - | expression tag |
| His 636 | - | expression tag |
| His 637 | - | expression tag |
| His 638 | - | expression tag |
| His 639 | - | expression tag |
| His 640 | - | expression tag |
| Met 641 | - | expression tag |
| Asp 642 | - | expression tag |
| Glu 643 | - | expression tag |
| Lys 644 | - | expression tag |
| Thr 645 | - | expression tag |
| Thr 646 | - | expression tag |
| Gly 647 | - | expression tag |
| Trp 648 | - | expression tag |
| Arg 649 | - | expression tag |
| Gly 650 | - | expression tag |
| Gly 651 | - | expression tag |
| His 652 | - | expression tag |
| Val 653 | - | expression tag |
| Val 654 | - | expression tag |
| Glu 655 | - | expression tag |
| Gly 656 | - | expression tag |
| Leu 657 | - | expression tag |
| Ala 658 | - | expression tag |
| Gly 659 | - | expression tag |
| Glu 660 | - | expression tag |
| Leu 661 | - | expression tag |
| Glu 662 | - | expression tag |
| Gln 663 | - | expression tag |
| Leu 664 | - | expression tag |
| Arg 665 | - | expression tag |
| Ala 666 | - | expression tag |
| Arg 667 | - | expression tag |
| Leu 668 | - | expression tag |
| Glu 669 | - | expression tag |
| His 670 | - | expression tag |
| His 671 | - | expression tag |
| Pro 672 | - | expression tag |
| Gln 673 | - | expression tag |
| Gly 674 | - | expression tag |
| Gln 675 | - | expression tag |
| Arg 676 | - | expression tag |
| Glu 677 | - | expression tag |
| Pro 678 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 73914.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 877.9 | |
| All* | Total formula weight | 74792.3 |
