7UV0
Structure of the sodium/iodide symporter (NIS) in complex with iodide and sodium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006590 | biological_process | thyroid hormone generation |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0008507 | molecular_function | sodium:iodide symporter activity |
| A | 0015111 | molecular_function | iodide transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015373 | molecular_function | monoatomic anion:sodium symporter activity |
| A | 0015705 | biological_process | iodide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071320 | biological_process | cellular response to cAMP |
| A | 0071371 | biological_process | cellular response to gonadotropin stimulus |
| A | 0098656 | biological_process | monoatomic anion transmembrane transport |
| A | 1904200 | biological_process | iodide transmembrane transport |
| A | 1904322 | biological_process | cellular response to forskolin |
| A | 1904401 | biological_process | cellular response to Thyroid stimulating hormone |
Functional Information from PROSITE/UniProt
| site_id | PS00456 |
| Number of Residues | 26 |
| Details | NA_SOLUT_SYMP_1 Sodium:solute symporter family signature 1. GldIwasLLSTGIIctlYTtvGGMkA |
| Chain | Residue | Details |
| A | GLY161-ALA186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR17-ALA37 | |
| A | LEU54-LEU74 | |
| A | TRP89-PHE109 | |
| A | TYR137-ASN157 | |
| A | ILE164-MET184 | |
| A | VAL187-ALA207 | |
| A | TYR242-ASN262 | |
| A | LEU287-TYR307 | |
| A | LEU327-ALA347 | |
| A | PHE392-VAL412 | |
| A | PHE417-LEU437 | |
| A | VAL445-LEU465 | |
| A | ILE521-ILE541 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 190 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG38-GLN53 | |
| A | TYR110-GLN136 | |
| A | LYS185-ALA186 | |
| A | GLN263-GLN286 | |
| A | TYR348-SER391 | |
| A | PRO438-GLY444 | |
| A | SER542-LEU618 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 126 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY75-LEU88 | |
| A | GLN158-ASP163 | |
| A | ARG208-ARG241 | |
| A | LYS308-PRO326 | |
| A | LEU413-SER416 | |
| A | TYR466-ALA520 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Required for homodimerization => ECO:0000250|UniProtKB:Q92911 |
| Chain | Residue | Details |
| A | TYR242 | |
| A | THR243 | |
| A | GLN471 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000255 |
| Chain | Residue | Details |
| A | SER551 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN485 | |
| A | GLN497 |
