7UV0

Structure of the sodium/iodide symporter (NIS) in complex with iodide and sodium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006590	biological_process	thyroid hormone generation
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0008507	molecular_function	sodium:iodide symporter activity
A	0015075	molecular_function	monoatomic ion transmembrane transporter activity
A	0015111	molecular_function	iodide transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015373	molecular_function	monoatomic anion:sodium symporter activity
A	0015705	biological_process	iodide transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035725	biological_process	sodium ion transmembrane transport
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0071320	biological_process	cellular response to cAMP
A	0071371	biological_process	cellular response to gonadotropin stimulus
A	1904200	biological_process	iodide transmembrane transport
A	1904322	biological_process	cellular response to forskolin
A	1904401	biological_process	cellular response to Thyroid stimulating hormone

Functional Information from PROSITE/UniProt

site_id	PS00456
Number of Residues	26
Details	NA_SOLUT_SYMP_1 Sodium:solute symporter family signature 1. GldIwasLLSTGIIctlYTtvGGMkA

Chain	Residue	Details
A	GLY161-ALA186

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	23
Details	Transmembrane: {"description":"Discontinuously helical; Name=2","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	77
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Discontinuously helical; Name=7","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36517601","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UV0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---