7TXH

Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Ras-related protein M-Ras	polymer	180	20567.5	2	UniProt (O14807) Pfam (PF00071) In PDB	Homo sapiens (human)	Ras-related protein R-Ras3
2	B, E	Leucine-rich repeat protein SHOC-2	polymer	505	56719.5	2	UniProt (Q9UQ13) Pfam (PF13855) In PDB	Homo sapiens (human)	Protein soc-2 homolog,Protein sur-8 homolog
3	C, F	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	297	33963.9	2	UniProt (P62136) Pfam (PF16891) Pfam (PF00149) In PDB	Homo sapiens (human)	PP-1A
4	A, D	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	2	Chemie (GNP)
5	A, D	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	E, F, A, B, C...	GLYCEROL	non-polymer		92.1	16	Chemie (GOL)
7	F, C	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
8	E, F, C	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
9		water	water		18.0	1715	Chemie (HOH)

Sequence modifications

A, D: 1 - 178 (UniProt: O14807)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag
Arg 71	Gln 71	variant

B, E: 80 - 582 (UniProt: Q9UQ13)

PDB	External Database	Details
Gly 78	-	expression tag
Pro 79	-	expression tag
Ile 173	Met 173	engineered mutation

C, F: 7 - 300 (UniProt: P62136)

PDB	External Database	Details
Ser 4	-	expression tag
Asn 5	-	expression tag
Ala 6	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	222501.8
Non-Polymers*	Number of molecules	28
	Total formula weight	3166.1
All*	Total formula weight	225668.0

*Water molecules are not included.