7TN9
Structure of the Inmazeb cocktail and resistance to escape against Ebola virus
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, S, T (A, C, E) | REGN3471 heavy chain | polymer | 217 | 23020.7 | 3 | Mus musculus (Mouse) | ||
| 2 | B, C, D (T, S, U) | Envelope glycoprotein | polymer | 321 | 35605.9 | 3 | UniProt (Q05320) Pfam (PF01611) | Ebola virus - Mayinga Zaire 1976 (ZEBOV Zaire Ebola virus) | GP1,2,GP |
| 3 | E, F, M (R, N, P) | REGN3479 light chain | polymer | 213 | 23228.7 | 3 | Mus musculus (Mouse) | ||
| 4 | G, U, V (F, B, D) | REGN3471 light chain | polymer | 220 | 24172.8 | 3 | Mus musculus (Mouse) | ||
| 5 | H, O, P (W, V, X) | GP2 | polymer | 140 | 15795.8 | 3 | UniProt (Q05320) Pfam (PF22307) | Ebola virus - Mayinga Zaire 1976 (ZEBOV Zaire Ebola virus) | |
| 6 | I, J, N (Q, M, O) | REGN3479 heavy chain | polymer | 217 | 22856.6 | 3 | Mus musculus (Mouse) | ||
| 7 | K, Q (G, I) | REGN3470 heavy chain | polymer | 215 | 23188.0 | 2 | Mus musculus (Mouse) | ||
| 8 | L, R (H, J) | REGN3470 light chain | polymer | 215 | 23474.1 | 2 | Mus musculus (Mouse) | ||
| 9 | W, X, Y (K, L, Y) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G34442SS) | |||
| 10 | AA, BA, CA, DA, EA... (T, S, U) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
T, S, U: 32 - 311 (UniProt: Q05320)
W, V, X: 503 - 637 (UniProt: Q05320)
| PDB | External Database | Details |
|---|---|---|
| Arg 31 | - | expression tag |
| Asn 312 | - | expression tag |
| Thr 313 | - | expression tag |
| His 314 | - | expression tag |
| His 315 | - | expression tag |
| Gln 316 | - | expression tag |
| Asp 317 | - | expression tag |
| Thr 318 | - | expression tag |
| Gly 319 | - | expression tag |
| Glu 320 | - | expression tag |
| Glu 321 | - | expression tag |
| Ser 322 | - | expression tag |
| Ala 323 | - | expression tag |
| Ser 324 | - | expression tag |
| Ser 325 | - | expression tag |
| Gly 326 | - | expression tag |
| Lys 327 | - | expression tag |
| Leu 328 | - | expression tag |
| Gly 329 | - | expression tag |
| Leu 330 | - | expression tag |
| Ile 331 | - | expression tag |
| Thr 332 | - | expression tag |
| Asn 333 | - | expression tag |
| Thr 334 | - | expression tag |
| Ile 335 | - | expression tag |
| Ala 336 | - | expression tag |
| Gly 337 | - | expression tag |
| Val 338 | - | expression tag |
| Ala 339 | - | expression tag |
| Gly 340 | - | expression tag |
| Leu 341 | - | expression tag |
| Ile 342 | - | expression tag |
| Thr 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Arg 346 | - | expression tag |
| Arg 347 | - | expression tag |
| Thr 348 | - | expression tag |
| Arg 349 | - | expression tag |
| Arg 350 | - | expression tag |
| Glu 351 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 544 | Ile 544 | conflict |
| Asp 638 | - | expression tag |
| Asp 639 | - | expression tag |
| Asp 640 | - | expression tag |
| Asp 641 | - | expression tag |
| Lys 642 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 22 |
| Total formula weight | 527365.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 3218.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 532354.0 |
