7TA6
Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Tumor necrosis factor | polymer | 158 | 17457.7 | 8 | UniProt (P01375) Pfam (PF00229) In PDB | Homo sapiens (human) | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a |
| 2 | I, J, K, L, M... | Alpha/Beta-peptide-1 | polymer | 29 | 3293.8 | 8 | Synthetic construct | ||
| 3 | K, N, A, B, C... | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 4 | H | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | L, M, N, O, P... | AMINO GROUP | non-polymer | 16.0 | 8 | Chemie (NH2) | |||
| 6 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 157 (UniProt: P01375)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 166012.6 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 663.8 | |
| All* | Total formula weight | 166676.5 |
