7TA6

Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005164	molecular_function	tumor necrosis factor receptor binding
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
B	0005164	molecular_function	tumor necrosis factor receptor binding
B	0006955	biological_process	immune response
B	0016020	cellular_component	membrane
C	0005164	molecular_function	tumor necrosis factor receptor binding
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
D	0005164	molecular_function	tumor necrosis factor receptor binding
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
E	0005164	molecular_function	tumor necrosis factor receptor binding
E	0006955	biological_process	immune response
E	0016020	cellular_component	membrane
F	0005164	molecular_function	tumor necrosis factor receptor binding
F	0006955	biological_process	immune response
F	0016020	cellular_component	membrane
G	0005164	molecular_function	tumor necrosis factor receptor binding
G	0006955	biological_process	immune response
G	0016020	cellular_component	membrane
H	0005164	molecular_function	tumor necrosis factor receptor binding
H	0006955	biological_process	immune response
H	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00251
Number of Residues	17
Details	THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF

Chain	Residue	Details
A	LEU48-PHE64

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	CARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000269|PubMed:8631363

Chain	Residue	Details
A	SER4
B	SER4
C	SER4
D	SER4
E	SER4
F	SER4
G	SER4
H	SER4

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