7T6B
Structure of S1PR2-heterotrimeric G13 signaling complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein subunit alpha-13 | polymer | 362 | 42255.3 | 1 | UniProt (Q14344) Pfam (PF00503) UniProt (by SIFTS) (P63096) | Homo sapiens (human) | G alpha-13,G-protein subunit alpha-13 |
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 362 | 39970.7 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
| 5 | E (R) | Sphingosine 1-phosphate receptor 2 | polymer | 361 | 39902.8 | 1 | UniProt (O95136) Pfam (PF00001) | Homo sapiens (human) | S1P receptor 2,S1P2,Endothelial differentiation G-protein coupled receptor 5,Sphingosine 1-phosphate receptor Edg-5,S1P receptor Edg-5 |
| 6 | F (R) | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate | non-polymer | 379.5 | 1 | Chemie (S1P) PubChem (5262) PubChem (44341320) PubChem (105065) PubChem (53780565) PubChem (57616144) PubChem (58085296) PubChem (58185636) PubChem (71684447) PubChem (5283560) PubChem (91130516) PubChem (91443267) PubChem (5280903) PubChem (5311444) PubChem (5353956) PubChem (93190681) PubChem (10309366) PubChem (123990699) |
Sequence modifications
A: 2 - 377 (UniProt: Q14344)
C: 2 - 340 (UniProt: P62873)
R: 1 - 353 (UniProt: O95136)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Thr 4 | Leu 19 | conflict |
| Ser 6 | Thr 21 | conflict |
| Ala 7 | Ser 22 | conflict |
| Glu 8 | Gly 23 | conflict |
| Asp 9 | Glu 24 | conflict |
| Lys 10 | Ala 25 | conflict |
| Ala 11 | Glu 26 | conflict |
| Ala 12 | Gln 27 | conflict |
| Val 13 | Gln 28 | conflict |
| Glu 14 | Arg 29 | conflict |
| Arg 15 | Lys 30 | conflict |
| Met 18 | Glu 33 | conflict |
| Arg 21 | Lys 36 | conflict |
| Asn 22 | Cys 37 | conflict |
| Arg 24 | Ser 39 | conflict |
| Glu 25 | Arg 40 | conflict |
| Asp 26 | Glu 41 | conflict |
| Gly 27 | Lys 42 | conflict |
| Glu 28 | Thr 43 | conflict |
| Lys 29 | Tyr 44 | conflict |
| Ala 30 | Val 45 | conflict |
| Ala 31 | Lys 46 | conflict |
| Val 302 | Ile 302 | conflict |
| Gly 332 | Asn 332 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 354 | - | expression tag |
| Tyr 355 | - | expression tag |
| Lys 356 | - | expression tag |
| Asp 357 | - | expression tag |
| Asp 358 | - | expression tag |
| Asp 359 | - | expression tag |
| Asp 360 | - | expression tag |
| Lys 361 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 157774.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 379.5 | |
| All* | Total formula weight | 158154.3 |
