7T6B
Structure of S1PR2-heterotrimeric G13 signaling complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein subunit alpha-13 | polymer | 362 | 42255.3 | 1 | UniProt (Q14344) Pfam (PF00503) UniProt (by SIFTS) (P63096) In PDB | Homo sapiens (human) | G alpha-13,G-protein subunit alpha-13 |
2 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 362 | 39970.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | E | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
5 | R | Sphingosine 1-phosphate receptor 2 | polymer | 361 | 39902.8 | 1 | UniProt (O95136) Pfam (PF00001) In PDB | Homo sapiens (human) | S1P receptor 2,S1P2,Endothelial differentiation G-protein coupled receptor 5,Sphingosine 1-phosphate receptor Edg-5,S1P receptor Edg-5 |
6 | R | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate | non-polymer | 379.5 | 1 | Chemie (S1P) |
Sequence modifications
A: 2 - 377 (UniProt: Q14344)
C: 2 - 340 (UniProt: P62873)
R: 1 - 353 (UniProt: O95136)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Thr 4 | Leu 19 | conflict |
Ser 6 | Thr 21 | conflict |
Ala 7 | Ser 22 | conflict |
Glu 8 | Gly 23 | conflict |
Asp 9 | Glu 24 | conflict |
Lys 10 | Ala 25 | conflict |
Ala 11 | Glu 26 | conflict |
Ala 12 | Gln 27 | conflict |
Val 13 | Gln 28 | conflict |
Glu 14 | Arg 29 | conflict |
Arg 15 | Lys 30 | conflict |
Met 18 | Glu 33 | conflict |
Arg 21 | Lys 36 | conflict |
Asn 22 | Cys 37 | conflict |
Arg 24 | Ser 39 | conflict |
Glu 25 | Arg 40 | conflict |
Asp 26 | Glu 41 | conflict |
Gly 27 | Lys 42 | conflict |
Glu 28 | Thr 43 | conflict |
Lys 29 | Tyr 44 | conflict |
Ala 30 | Val 45 | conflict |
Ala 31 | Lys 46 | conflict |
Val 302 | Ile 302 | conflict |
Gly 332 | Asn 332 | conflict |
PDB | External Database | Details |
---|---|---|
Met -21 | - | initiating methionine |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 354 | - | expression tag |
Tyr 355 | - | expression tag |
Lys 356 | - | expression tag |
Asp 357 | - | expression tag |
Asp 358 | - | expression tag |
Asp 359 | - | expression tag |
Asp 360 | - | expression tag |
Lys 361 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 157774.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 379.5 | |
All* | Total formula weight | 158154.3 |