7T2P
The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Envelope glycoprotein gp120 | polymer | 527 | 60324.4 | 1 | UniProt (A0A5C0E975) Pfam (PF00516) UniProt (by SIFTS) (Q5QG95) In PDB | Simian immunodeficiency virus | |
| 2 | B | Envelope glycoprotein gp41 | polymer | 159 | 18144.6 | 1 | UniProt (L7XFX7) Pfam (PF00517) UniProt (by SIFTS) (Q5QG95) In PDB | Simian immunodeficiency virus | |
| 3 | H | K11 Fab heavy chain | polymer | 485 | 53290.8 | 1 | Macaca mulatta | ||
| 4 | L | K11 Fab light chain | polymer | 232 | 25293.2 | 1 | Macaca mulatta | ||
| 5 | C | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G34499SX) | |||
| 6 | D, K, M, O, P | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 7 | E, F, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 8 | I | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 9 | J | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 10 | N | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 11 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) |
Sequence modifications
A: 1 - 525 (UniProt: A0A5C0E975)
B: 528 - 675 (UniProt: L7XFX7)
| PDB | External Database | Details |
|---|---|---|
| Ser 180 | Lys 180 | engineered mutation |
| Ser 511 | Asp 511 | conflict |
| Cys 512 | Val 512 | conflict |
| Arg 523 | Asn 523 | conflict |
| Arg 526 | - | expression tag |
| Arg 527 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 574 | Val 561 | conflict |
| Cys 620 | His 607 | conflict |
| Gly 676 | - | expression tag |
| Ser 677 | - | expression tag |
| Gly 678 | - | expression tag |
| His 679 | - | expression tag |
| His 680 | - | expression tag |
| His 681 | - | expression tag |
| His 682 | - | expression tag |
| His 683 | - | expression tag |
| His 684 | - | expression tag |
| His 685 | - | expression tag |
| His 686 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 157053.0 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 7801.2 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2875.7 | |
| All* | Total formula weight | 167729.9 |
