7T10
CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Somatostatin receptor type 2,Kappa-type opioid receptor | polymer | 408 | 45784.2 | 1 | UniProt (P30874) UniProt (P41145) Pfam (PF00001) In PDB | Homo sapiens (human) | |
2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-3 | polymer | 354 | 40584.2 | 1 | UniProt (P08754) Pfam (PF00503) In PDB | Homo sapiens (human) | G(i) alpha-3 |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
4 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | P | Somatostatin-14 | polymer | 14 | 1641.9 | 1 | UniProt (P61278) Pfam (PF03002) In PDB | Homo sapiens | SST-14 |
6 | S | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
7 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
R: 1 - 235 (UniProt: P30874)
R: 236 - 252 (UniProt: P41145)
R: 253 - 369 (UniProt: P30874)
A: 1 - 354 (UniProt: P08754)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Asp -38 | - | expression tag |
Tyr -37 | - | expression tag |
Lys -36 | - | expression tag |
Asp -35 | - | expression tag |
Asp -34 | - | expression tag |
Asp -33 | - | expression tag |
Asp -32 | - | expression tag |
Ala -31 | - | expression tag |
Met -30 | - | expression tag |
Gly -29 | - | expression tag |
Gln -28 | - | expression tag |
Pro -27 | - | expression tag |
Gly -26 | - | expression tag |
Asn -25 | - | expression tag |
Gly -24 | - | expression tag |
Ser -23 | - | expression tag |
Ala -22 | - | expression tag |
Phe -21 | - | expression tag |
Leu -20 | - | expression tag |
Leu -19 | - | expression tag |
Ala -18 | - | expression tag |
Pro -17 | - | expression tag |
Asn -16 | - | expression tag |
Arg -15 | - | expression tag |
Ser -14 | - | expression tag |
His -13 | - | expression tag |
Ala -12 | - | expression tag |
Pro -11 | - | expression tag |
Asp -10 | - | expression tag |
His -9 | - | expression tag |
Asp -8 | - | expression tag |
Val -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
R: 253 - 369 (UniProt: P30874)
A: 1 - 354 (UniProt: P08754)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 161327.4 | |
All* | Total formula weight | 161327.4 |