7SZC
Crystal Structure Analysis of human PRPK complex with a compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | EKC/KEOPS complex subunit TP53RK | polymer | 255 | 28358.6 | 2 | UniProt (Q96S44) Pfam (PF06293) | Homo sapiens (human) | Atypical serine/threonine protein kinase TP53RK,Nori-2,TP53-regulating kinase,p53-related protein kinase |
| 2 | B, D (B, D) | EKC/KEOPS complex subunit TPRKB | polymer | 178 | 19976.2 | 2 | UniProt (Q9Y3C4) Pfam (PF08617) | Homo sapiens (human) | PRPK-binding protein,TP53RK-binding protein |
| 3 | E, G (A, C) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 2 | Chemie (TAR) | |||
| 4 | F, H (A, C) | 4-hydroxy-2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione | non-polymer | 288.3 | 2 | Chemie (DO0) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 654 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 253 (UniProt: Q96S44)
B, D: 1 - 175 (UniProt: Q9Y3C4)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96669.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 876.7 | |
| All* | Total formula weight | 97546.4 |
