7SZC

Crystal Structure Analysis of human PRPK complex with a compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	EKC/KEOPS complex subunit TP53RK	polymer	255	28358.6	2	UniProt (Q96S44) Pfam (PF06293) In PDB	Homo sapiens (human)	Atypical serine/threonine protein kinase TP53RK,Nori-2,TP53-regulating kinase,p53-related protein kinase
2	B, D	EKC/KEOPS complex subunit TPRKB	polymer	178	19976.2	2	UniProt (Q9Y3C4) Pfam (PF08617) In PDB	Homo sapiens (human)	PRPK-binding protein,TP53RK-binding protein
3	A, C	D(-)-TARTARIC ACID	non-polymer		150.1	2	Chemie (TAR)
4	A, C	4-hydroxy-2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione	non-polymer		288.3	2	Chemie (DO0)
5		water	water		18.0	654	Chemie (HOH)

Sequence modifications

A, C: 1 - 253 (UniProt: Q96S44)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag

B, D: 1 - 175 (UniProt: Q9Y3C4)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	96669.7
Non-Polymers*	Number of molecules	4
	Total formula weight	876.7
All*	Total formula weight	97546.4

*Water molecules are not included.