7SZC

Crystal Structure Analysis of human PRPK complex with a compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000408	cellular_component	EKC/KEOPS complex
A	0002039	molecular_function	p53 binding
A	0003824	molecular_function	catalytic activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0008033	biological_process	tRNA processing
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
A	0106310	molecular_function	protein serine kinase activity
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1990145	biological_process	maintenance of translational fidelity
B	0000408	cellular_component	EKC/KEOPS complex
B	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008033	biological_process	tRNA processing
B	0019901	molecular_function	protein kinase binding
B	1990145	biological_process	maintenance of translational fidelity
C	0000166	molecular_function	nucleotide binding
C	0000408	cellular_component	EKC/KEOPS complex
C	0002039	molecular_function	p53 binding
C	0003824	molecular_function	catalytic activity
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006468	biological_process	protein phosphorylation
C	0008033	biological_process	tRNA processing
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016787	molecular_function	hydrolase activity
C	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
C	0106310	molecular_function	protein serine kinase activity
C	1901796	biological_process	regulation of signal transduction by p53 class mediator
C	1990145	biological_process	maintenance of translational fidelity
D	0000408	cellular_component	EKC/KEOPS complex
D	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008033	biological_process	tRNA processing
D	0019901	molecular_function	protein kinase binding
D	1990145	biological_process	maintenance of translational fidelity

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LIHgDLTTSNMLL

Chain	Residue	Details
A	LEU158-LEU170

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---