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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7SYV

Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(2)		18S rRNApolymer1870603100.91Oryctolagus cuniculus (rabbit)
2B
(Z)		40S ribosomal protein S24polymer13115237.11UniProt (A0A5F9CNN4)
Pfam (PF01282)
UniProt (by SIFTS) (G1T3D8)		Oryctolagus cuniculus (rabbit)
3C
(A)		Eukaryotic translation initiation factor 1A, X-chromosomalpolymer14416488.41UniProt (P47813)
Pfam (PF01176)		Homo sapiens (human)eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C
4D
(a)		40S ribosomal protein S25polymer12413645.01UniProt (G1TDB3)
Pfam (PF03297)		Oryctolagus cuniculus (rabbit)
5E
(B)		40S ribosomal protein SApolymer29532958.01UniProt (G1TLT8)
Pfam (PF00318)
Pfam (PF16122)		Oryctolagus cuniculus (rabbit)37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
6F
(b)		eS26polymer10111645.81UniProt (G1TFE8)
Pfam (PF01283)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S26
7G
(C)		eS1polymer26430002.11UniProt (G1SS70)
Pfam (PF01015)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S3a
8H
(c)		eS27polymer849480.21UniProt (G1TZ76)
Pfam (PF01667)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S27
9I
(D)		40S ribosomal protein S2polymer22124441.81UniProt (G1TUT9)Oryctolagus cuniculus (rabbit)
10J
(d)		eS28polymer697855.11UniProt (G1TIB4)
Pfam (PF01200)		Oryctolagus cuniculus (rabbit)Ribosomal protein S28
11K
(E)		uS3polymer28131146.61UniProt (G1TNM3)
Pfam (PF07650)
Pfam (PF00189)		Oryctolagus cuniculus (rabbit)Ribosomal protein S3
12L
(e)		eS29polymer566690.81UniProt (G1U7M4)
Pfam (PF00253)		Oryctolagus cuniculus (rabbit)
13M
(F)		40S ribosomal protein S4polymer26329654.91UniProt (G1TK17)
Pfam (PF00467)
Pfam (PF16121)
Pfam (PF08071)
Pfam (PF00900)
UniProt (by SIFTS) (G1TA47)		Oryctolagus cuniculus (rabbit)
14N
(f)		eS30polymer13314498.91UniProt (G1T8A2)
Pfam (PF00240)
Pfam (PF04758)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S30
15O
(G)		uS7polymer20422913.51UniProt (G1TFM5)
Pfam (PF00177)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S5
16P
(g)		40S ribosomal protein S27apolymer18821431.71UniProt (G1SK22)
Pfam (PF00240)
Pfam (PF01599)		Oryctolagus cuniculus (rabbit)Ubiquitin carboxyl extension protein 80,Ubiquitin-40S ribosomal protein S27a
17Q
(H)		eS6polymer24928751.91UniProt (G1TM55)
Pfam (PF01092)
UniProt (by SIFTS) (A0A5K1UJS7)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S6
18R
(h)		RACK1polymer31735115.71UniProt (G1SJB4)
Pfam (PF00400)		Oryctolagus cuniculus (rabbit)
19S
(I)		40S ribosomal protein S7polymer43247356.21UniProt (G1SVB0)
Pfam (PF01251)		Oryctolagus cuniculus (rabbit)
20T
(i)		Met-tRNA-i-Metpolymer7524231.51GenBank (174924)Oryctolagus cuniculus (rabbit)
21U
(J)		eS8polymer20824263.41UniProt (G1TJW1)
Pfam (PF01201)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S8
22V
(n)		60s ribosomal protein l41polymer253473.51UniProt (A0A087WNH4)
Pfam (PF05162)		Oryctolagus cuniculus (rabbit)
23W
(K)		uS4polymer19422641.61UniProt (B7NZS8)
Pfam (PF00163)
Pfam (PF01479)		Oryctolagus cuniculus (rabbit)Ribosomal protein S9
24X
(x)		Eukaryotic translation initiation factor 5Bpolymer62770788.01UniProt (G1TRL5)
Pfam (PF00009)
Pfam (PF11987)
Pfam (PF14578)		Oryctolagus cuniculus (rabbit)Translation initiation factor IF-2
25Y
(L)		eS10polymer14917156.91UniProt (G1TPV3)
Pfam (PF03501)		Oryctolagus cuniculus (rabbit)
26Z
(z)		HCV IRESpolymer400128746.11GenBank (149384897)hepatitis C virus genotype 1a
27AA
(M)		uS17polymer15818468.81UniProt (G1TRM4)
Pfam (PF16205)
Pfam (PF00366)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S11
28BA
(N)		eS12polymer13214539.01UniProt (G1SFR8)
Pfam (PF01248)		Oryctolagus cuniculus (rabbit)40S ribosomal protein S12
29CA
(O)		uS15polymer15117259.41UniProt (G1SP51)
Pfam (PF08069)
Pfam (PF00312)		Oryctolagus cuniculus (rabbit)Ribosomal protein S13
30DA
(P)		uS11polymer16818134.01UniProt (G1U472)
Pfam (PF00411)
UniProt (by SIFTS) (G1T1F0)		Oryctolagus cuniculus (rabbit)
31EA
(Q)		uS19polymer14517049.21UniProt (G1U0Q2)
Pfam (PF00203)		Oryctolagus cuniculus (rabbit)
32FA
(R)		uS9polymer17219213.51UniProt (G1SGX4)
Pfam (PF00380)		Oryctolagus cuniculus (rabbit)Ribosomal protein S16
33GA
(S)		eS17polymer13515552.11UniProt (G1TU13)
Pfam (PF00833)		Oryctolagus cuniculus (rabbit)
34HA
(T)		uS13polymer15217759.81UniProt (G1TPG3)
Pfam (PF00416)		Oryctolagus cuniculus (rabbit)
35IA
(U)		eS19polymer14516235.81UniProt (G1TN62)
Pfam (PF01090)		Oryctolagus cuniculus (rabbit)
36JA
(V)		uS10polymer11913398.81UniProt (G1SIZ2)
Pfam (PF00338)		Oryctolagus cuniculus (rabbit)
37KA
(W)		40S ribosomal protein S21polymer839124.41UniProt (G1TM82)
Pfam (PF01249)		Oryctolagus cuniculus (rabbit)
38LA
(X)		uS8polymer13014865.61UniProt (G1TG89)
Pfam (PF00410)		Oryctolagus cuniculus (rabbit)Ribosomal protein S15a
39MA
(Y)		uS12polymer14315844.71UniProt (G1SZ47)
Pfam (PF00164)		Oryctolagus cuniculus (rabbit)
40NA, OA
(b, g)		ZINC IONnon-polymer65.42Chemie (ZN)
41PA
(x)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
PubChem (177679032)
PubChem (135400627)
PubChem (135487750)
PubChem (136088935)
PubChem (136803486)
PubChem (135398633)
PubChem (135544356)
PubChem (135547949)
PubChem (135600366)
PubChem (135749822)
PubChem (136005188)
PubChem (136073923)
PubChem (136240914)
PubChem (136664747)
PubChem (136772743)
PubChem (136772744)
PubChem (136803487)
PubChem (137286749)
PubChem (164715984)
PubChem (171699466)
42QA
(x)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
PubChem (888)
43RA
(x)		SODIUM IONnon-polymer23.01Chemie (NA)
PubChem (923)
Sequence modifications
B: 1 - 295 (UniProt: G1TLT8)
PDBExternal DatabaseDetails
Thr 114Ala 114conflict
b: 2 - 102 (UniProt: G1TFE8)
PDBExternal DatabaseDetails
Arg 28Cys 28conflict
Ala 56Val 56conflict
D: 58 - 278 (UniProt: G1TUT9)
PDBExternal DatabaseDetails
Met 73Val 50conflict
Ser 101Ala 78conflict
Gly 119Ala 96conflict
Arg 194His 171conflict
Met 215Leu 192conflict
Arg 227Trp 204conflict
Gly 228Ser 205conflict
F: 1 - 263 (UniProt: G1TK17)
PDBExternal DatabaseDetails
Gly 25Ser 25conflict
Arg 51Lys 51conflict
Thr 78Ala 78conflict
Val 156Met 156conflict
J: 1 - 208 (UniProt: G1TJW1)
PDBExternal DatabaseDetails
Arg 47Gly 47conflict
W: 1 - 83 (UniProt: G1TM82)
PDBExternal DatabaseDetails
Asn 3Ser 3conflict
Asp 4Asn 4conflict
Gln 33Pro 33conflict
Phe 50Ser 50conflict
Ala 75Ser 75conflict
Asp 76His 76conflict
Lys 81Gln 81conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains39
Total formula weight1501160.4
Non-Polymers*Number of molecules5
Total formula weight701.3
All*Total formula weight1501861.7
*Water molecules are not included.

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PDB entries from 2026-05-06

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