7STG
Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, AA, C, CA, E... (A, C, E, G, I...) | RPA-related protein RADX peptide,Beta-2-microglobulin,MHC class I antigen chimera | polymer | 423 | 47523.2 | 16 | UniProt (Q6NSI4) UniProt (P16213) UniProt (A0A678ZGP6) Pfam (PF07654) Pfam (PF00129) | Homo sapiens (Human) | RPA-related and RAD51-antagonist,X-chromosome |
| 2 | B, BA, D, DA, F... (B, D, F, H, J...) | VHH | polymer | 116 | 12536.8 | 16 | Lama glama | ||
| 3 | AB, BB, CB, DB, EB... (X, Z, b, d, e...) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K, M, O, Q, S, U, W, Y, a, c, e: 2 - 9 (UniProt: Q6NSI4)
A, C, E, G, I, K, M, O, Q, S, U, W, Y, a, c, e: 25 - 123 (UniProt: P16213)
A, C, E, G, I, K, M, O, Q, S, U, W, Y, a, c, e: 144 - 418 (UniProt: A0A678ZGP6)
| PDB | External Database | Details |
|---|---|---|
| Gly 10 | - | linker |
| Gly 11 | - | linker |
| Gly 12 | - | linker |
| Gly 13 | - | linker |
| Ser 14 | - | linker |
| Gly 15 | - | linker |
| Gly 16 | - | linker |
| Gly 17 | - | linker |
| Gly 18 | - | linker |
| Ser 19 | - | linker |
| Gly 20 | - | linker |
| Gly 21 | - | linker |
| Gly 22 | - | linker |
| Gly 23 | - | linker |
| Ser 24 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | linker |
| Gly 125 | - | linker |
| Gly 126 | - | linker |
| Gly 127 | - | linker |
| Ser 128 | - | linker |
| Gly 129 | - | linker |
| Gly 130 | - | linker |
| Gly 131 | - | linker |
| Gly 132 | - | linker |
| Ser 133 | - | linker |
| Gly 134 | - | linker |
| Gly 135 | - | linker |
| Gly 136 | - | linker |
| Gly 137 | - | linker |
| Ser 138 | - | linker |
| Gly 139 | - | linker |
| Gly 140 | - | linker |
| Gly 141 | - | linker |
| Gly 142 | - | linker |
| Ser 143 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Cys 227 | Tyr 108 | engineered mutation |
| Cys 282 | Ala 163 | engineered mutation |
| His 419 | - | expression tag |
| His 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 32 |
| Total formula weight | 960960.7 | |
| All* | Total formula weight | 960960.7 |
