7RHK
Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D (C, A, D) | cGMP-gated cation channel alpha-1 | polymer | 560 | 64650.4 | 3 | UniProt (P29973) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526) | Homo sapiens (Human) | Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,CNG1,Cyclic nucleotide-gated channel,photoreceptor,Rod photoreceptor cGMP-gated channel subunit alpha |
| 2 | B (B) | Cyclic nucleotide-gated cation channel beta-1 | polymer | 810 | 91039.3 | 1 | UniProt (Q14028) Pfam (PF00027) | Homo sapiens (Human) | Cyclic nucleotide-gated cation channel 4,CNG channel 4,CNG-4,CNG4,Cyclic nucleotide-gated cation channel gamma,Cyclic nucleotide-gated cation channel modulatory subunit,Cyclic nucleotide-gated channel beta-1,CNG channel beta-1,Glutamic acid-rich protein,GARP |
| 3 | E, F, G, I (C, B, A, D) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 4 | Chemie (PCG) | |||
| 4 | H (A) | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate | non-polymer | 414.5 | 1 | Chemie (5H0) |
Sequence modifications
C, A, D: 144 - 690 (UniProt: P29973)
B: 454 - 1251 (UniProt: Q14028)
| PDB | External Database | Details |
|---|---|---|
| Met 131 | - | expression tag |
| Asp 132 | - | expression tag |
| Tyr 133 | - | expression tag |
| Lys 134 | - | expression tag |
| Asp 135 | - | expression tag |
| Asp 136 | - | expression tag |
| Asp 137 | - | expression tag |
| Asp 138 | - | expression tag |
| Lys 139 | - | expression tag |
| Gly 140 | - | expression tag |
| Gly 141 | - | expression tag |
| Ser 142 | - | expression tag |
| Ala 143 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 442 | - | expression tag |
| Asp 443 | - | expression tag |
| Tyr 444 | - | expression tag |
| Lys 445 | - | expression tag |
| Asp 446 | - | expression tag |
| Asp 447 | - | expression tag |
| Asp 448 | - | expression tag |
| Asp 449 | - | expression tag |
| Lys 450 | - | expression tag |
| Gly 451 | - | expression tag |
| Gly 452 | - | expression tag |
| Ser 453 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 284990.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1795.3 | |
| All* | Total formula weight | 286785.9 |
