7RE7
TCR mimic antibody (Fab fragment) in complex with AFP/HLA-A*02
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (I, H) | Fab heavy chain | polymer | 224 | 24069.0 | 2 | Homo sapiens (human) | ||
| 2 | B, D (J, L) | Fab light chain | polymer | 216 | 22877.2 | 2 | Homo sapiens (human) | ||
| 3 | E, G (A, D) | MHC class I antigen | polymer | 295 | 33950.5 | 2 | UniProt (Q861F7) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (A0A140T913) | Homo sapiens (Human) | |
| 4 | F, H (B, E) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 5 | I, J (C, F) | PHE-MET-ASN-LYS-PHE-ILE-TYR-GLU-ILE | polymer | 9 | 1205.4 | 2 | UniProt (by SIFTS) (P02771) | Homo sapiens | |
| 6 | K, M, T (I, H, B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 3 | Chemie (EPE) | |||
| 7 | BA, CA, L, N, O... (E, I, H, A, D) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 8 | Q, R, Y, Z (A, D, E) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 4 | Chemie (PG4) | |||
| 9 | S (B) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
| 10 | AA, U (E, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 11 | V (D) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 12 | W (D) | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 13 | DA, EA, FA, GA, HA... (I, J, H, L, A...) | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 278 (UniProt: Q861F7)
B, E: 2 - 100 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Gly 277 | Ser 277 | conflict |
| Gly 279 | - | expression tag |
| Gly 280 | - | expression tag |
| Gly 281 | - | expression tag |
| Leu 282 | - | expression tag |
| Asn 283 | - | expression tag |
| Asp 284 | - | expression tag |
| Ile 285 | - | expression tag |
| Phe 286 | - | expression tag |
| Glu 287 | - | expression tag |
| Ala 288 | - | expression tag |
| Gln 289 | - | expression tag |
| Lys 290 | - | expression tag |
| Ile 291 | - | expression tag |
| Gly 292 | - | expression tag |
| Trp 293 | - | expression tag |
| His 294 | - | expression tag |
| Glu 295 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 187962.8 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 3003.5 | |
| All* | Total formula weight | 190966.3 |
