7RE7
TCR mimic antibody (Fab fragment) in complex with AFP/HLA-A*02
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | I, H | Fab heavy chain | polymer | 224 | 24069.0 | 2 | Homo sapiens (human) | ||
2 | J, L | Fab light chain | polymer | 216 | 22877.2 | 2 | Homo sapiens (human) | ||
3 | A, D | MHC class I antigen | polymer | 295 | 33950.5 | 2 | UniProt (Q861F7) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (A0A140T913) In PDB | Homo sapiens (Human) | |
4 | B, E | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
5 | C, F | PHE-MET-ASN-LYS-PHE-ILE-TYR-GLU-ILE | polymer | 9 | 1205.4 | 2 | UniProt (by SIFTS) (P02771) In PDB | Homo sapiens | |
6 | I, H, B | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 3 | Chemie (EPE) | |||
7 | E, I, H, A, D | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
8 | A, D, E | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 4 | Chemie (PG4) | |||
9 | B | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) | |||
10 | E, B | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
11 | D | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
12 | D | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
13 | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 278 (UniProt: Q861F7)
B, E: 2 - 100 (UniProt: P61769)
PDB | External Database | Details |
---|---|---|
Gly 277 | Ser 277 | conflict |
Gly 279 | - | expression tag |
Gly 280 | - | expression tag |
Gly 281 | - | expression tag |
Leu 282 | - | expression tag |
Asn 283 | - | expression tag |
Asp 284 | - | expression tag |
Ile 285 | - | expression tag |
Phe 286 | - | expression tag |
Glu 287 | - | expression tag |
Ala 288 | - | expression tag |
Gln 289 | - | expression tag |
Lys 290 | - | expression tag |
Ile 291 | - | expression tag |
Gly 292 | - | expression tag |
Trp 293 | - | expression tag |
His 294 | - | expression tag |
Glu 295 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 187962.8 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 3003.5 | |
All* | Total formula weight | 190966.3 |