7RDT

Structure of human NTHL1 - linker 1 chimera

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Isoform 3 of Endonuclease III-like protein 1	polymer	250	27930.1	1	UniProt (P78549-3) Pfam (PF00730) Pfam (PF00633) UniProt (by SIFTS) (P78549) In PDB	Homo sapiens (Human)	hNTH1,Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase,DNA glycosylase/AP lyase,hNTH1,Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase,DNA glycosylase/AP lyase
2	A	IRON/SULFUR CLUSTER	non-polymer		351.6	1	Chemie (SF4)
3		water	water		18.0	199	Chemie (HOH)

Sequence modifications

A: 64 - 109 (UniProt: P78549-3)

PDB	External Database	Details
Met 63	-	initiating methionine

A: 118 - 305 (UniProt: P78549-3)

PDB	External Database	Details
Thr 110	-	linker
Thr 111	-	linker
Glu 112	-	linker
Leu 113	-	linker
Asn 114	-	linker
Phe 115	-	linker
Ser 116	-	linker
Ser 117	-	linker
Glu 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27930.1
Non-Polymers*	Number of molecules	1
	Total formula weight	351.6
All*	Total formula weight	28281.8

*Water molecules are not included.