7RDT
Structure of human NTHL1 - linker 1 chimera
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003906 | molecular_function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006285 | biological_process | base-excision repair, AP site formation |
| A | 0019104 | molecular_function | DNA N-glycosylase activity |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PROSITE/UniProt
| site_id | PS01155 |
| Number of Residues | 30 |
| Details | ENDONUCLEASE_III_2 Endonuclease III family signature. GdIPasvaeLva.LPGVGpkmAhlaMavAWG |
| Chain | Residue | Details |
| A | GLY195-GLY224 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; for N-glycosylase activity => ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:9705289 |
| Chain | Residue | Details |
| A | LYS213 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03183 |
| Chain | Residue | Details |
| A | CYS283 | |
| A | CYS290 | |
| A | CYS293 | |
| A | CYS299 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Important for catalytic activity |
| Chain | Residue | Details |
| A | ASP232 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER71 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER73 |
