7RDT
Structure of human NTHL1 - linker 1 chimera
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003906 | molecular_function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006285 | biological_process | base-excision repair, AP site formation |
| A | 0019104 | molecular_function | DNA N-glycosylase activity |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PROSITE/UniProt
| site_id | PS01155 |
| Number of Residues | 30 |
| Details | ENDONUCLEASE_III_2 Endonuclease III family signature. GdIPasvaeLva.LPGVGpkmAhlaMavAWG |
| Chain | Residue | Details |
| A | GLY195-GLY224 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Domain: {"description":"HhH","evidences":[{"source":"HAMAP-Rule","id":"MF_03183","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for N-glycosylase activity","evidences":[{"source":"HAMAP-Rule","id":"MF_03183","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9705289","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03183","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity"} |
| Chain | Residue | Details |
