7RA3
cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-3,Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 373 | 43385.2 | 1 | UniProt (P08754) UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | G(i) alpha-3,Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (E) | Single-chain variable fragment 16 | polymer | 297 | 31870.6 | 1 | Mus musculus | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (N) | Nanobody 35 | polymer | 160 | 17352.5 | 1 | Lama glama | ||
| 6 | F (P) | Gastric inhibitory polypeptide | polymer | 42 | 4990.6 | 1 | UniProt (P09681) Pfam (PF00123) | Homo sapiens | GIP,Glucose-dependent insulinotropic polypeptide,Incretin hormone |
| 7 | G (R) | Gastric inhibitory polypeptide receptor | polymer | 463 | 52871.8 | 1 | UniProt (P48546) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | GIP-R,Glucose-dependent insulinotropic polypeptide receptor |
Sequence modifications
A: 8 - 25 (UniProt: P08754)
A: 26 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
R: 22 - 466 (UniProt: P48546)
A: 26 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Lys 6 | - | expression tag |
| Asp 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Asp 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Val 16 | - | expression tag |
| Leu 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Pro 21 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 196866.0 | |
| All* | Total formula weight | 196866.0 |
