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7RA3

cryo-EM of human Gastric inhibitory polypeptide receptor GIPR bound to GIP

Functional Information from GO Data
ChainGOidnamespacecontents
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0003091biological_processrenal water homeostasis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007608biological_processsensory perception of smell
A0010856molecular_functionadenylate cyclase activator activity
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031748molecular_functionD1 dopamine receptor binding
A0032588cellular_componenttrans-Golgi network membrane
A0046872molecular_functionmetal ion binding
A0046907biological_processintracellular transport
A0048589biological_processdevelopmental growth
A0050796biological_processregulation of insulin secretion
A0050890biological_processcognition
A0060348biological_processbone development
A0060789biological_processhair follicle placode formation
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0071377biological_processcellular response to glucagon stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
P0005179molecular_functionhormone activity
P0005576cellular_componentextracellular region
P0009749biological_processresponse to glucose
P0042304biological_processregulation of fatty acid biosynthetic process
P0050796biological_processregulation of insulin secretion
R0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
R0004888molecular_functiontransmembrane signaling receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006091biological_processgeneration of precursor metabolites and energy
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007190biological_processactivation of adenylate cyclase activity
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007584biological_processresponse to nutrient
R0008528molecular_functionG protein-coupled peptide receptor activity
R0009749biological_processresponse to glucose
R0016020cellular_componentmembrane
R0016519molecular_functiongastric inhibitory peptide receptor activity
R0017046molecular_functionpeptide hormone binding
R0031018biological_processendocrine pancreas development
R0032024biological_processpositive regulation of insulin secretion
R0038192biological_processgastric inhibitory peptide signaling pathway
R0043950biological_processpositive regulation of cAMP-mediated signaling
R0048678biological_processresponse to axon injury
R0050796biological_processregulation of insulin secretion
R0051592biological_processresponse to calcium ion
R0070542biological_processresponse to fatty acid
R0120022molecular_functionglucagon family peptide binding
Functional Information from PROSITE/UniProt
site_idPS00260
Number of Residues23
DetailsGLUCAGON Glucagon / GIP / secretin / VIP family signature. YAEGTFiSDYsiamdkihQQDFV
ChainResidueDetails
PTYR1-VAL23

site_idPS00649
Number of Residues25
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CngsFDmyv.CWdyAapnatarasCP
ChainResidueDetails
RCYS61-PRO85

site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFLVsVLYCFiNkeV
ChainResidueDetails
RGLN384-VAL399

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues171
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RARG22-GLN138
RARG190-ARG217
RTYR279-LYS293
RGLU363-GLU377

site_idSWS_FT_FI2
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RVAL139-LEU161

site_idSWS_FT_FI3
Number of Residues106
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RPHE162-ARG169
RSER243-GLY254
RILE320-ARG341
RVAL399-CYS466
ACYS237
ASER306
AARG380

site_idSWS_FT_FI4
Number of Residues19
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RASN170-SER189

site_idSWS_FT_FI5
Number of Residues24
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RTHR218-HIS242

site_idSWS_FT_FI6
Number of Residues23
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RHIS255-ARG278

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RALA294-GLY319

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RSER342-GLU362

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RILE378-GLU398

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22412906
ChainResidueDetails
RASN62
RASN77

227111

PDB entries from 2024-11-06

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