7R58
Crystal structure of the GPVI-glenzocimab complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet glycoprotein VI | polymer | 204 | 22570.3 | 1 | UniProt (Q9HCN6) Pfam (PF13895) Pfam (PF13927) | Homo sapiens (human) | GPVI,Glycoprotein 6 |
| 2 | B (H) | Fab heavy chain | polymer | 227 | 24250.1 | 1 | Mus musculus | ||
| 3 | C (L) | Fab light chain | polymer | 219 | 24105.7 | 1 | Mus musculus | ||
| 4 | D, E, I, J, K... (A, H, L) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 5 | F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | H (A) | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 7 | M, N, O (A, H, L) | water | water | 18.0 | 779 | Chemie (HOH) |
Sequence modifications
A: 1 - 183 (UniProt: Q9HCN6)
| PDB | External Database | Details |
|---|---|---|
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Val -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70926.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 681.6 | |
| All* | Total formula weight | 71607.7 |
