7R58

Crystal structure of the GPVI-glenzocimab complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Platelet glycoprotein VI	polymer	204	22570.3	1	UniProt (Q9HCN6) Pfam (PF13895) Pfam (PF13927) In PDB	Homo sapiens (human)	GPVI,Glycoprotein 6
2	H	Fab heavy chain	polymer	227	24250.1	1		Mus musculus
3	L	Fab light chain	polymer	219	24105.7	1		Mus musculus
4	A, H, L	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
5	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	A	THIOCYANATE ION	non-polymer		58.1	1	Chemie (SCN)
7		water	water		18.0	779	Chemie (HOH)

Sequence modifications

A: 1 - 183 (UniProt: Q9HCN6)

PDB	External Database	Details
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	70926.2
Non-Polymers*	Number of molecules	9
	Total formula weight	681.6
All*	Total formula weight	71607.7

*Water molecules are not included.