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7QOO

Structure of the human inner kinetochore CCAN complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(C)
Centromere protein Cpolymer54461856.01UniProt (Q03188)
Pfam (PF15622)
Pfam (PF15620)
Homo sapiens (human)CENP-C,Centromere autoantigen C,Centromere protein C 1,CENP-C 1,Interphase centromere complex protein 7
2B
(H)
Centromere protein Hpolymer24728520.91UniProt (Q9H3R5)
Pfam (PF05837)
Homo sapiens (human)CENP-H,Interphase centromere complex protein 35
3C
(I)
Centromere protein Ipolymer75686820.21UniProt (Q92674)
Pfam (PF07778)
Homo sapiens (human)CENP-I,FSH primary response protein 1,Follicle-stimulating hormone primary response protein,Interphase centromere complex protein 19,Leucine-rich primary response protein 1
4D
(K)
Centromere protein Kpolymer26931696.11UniProt (Q9BS16)
Pfam (PF11802)
Homo sapiens (human)CENP-K,Interphase centromere complex protein 37,Protein AF-5alpha,p33
5E
(L)
Centromere protein Lpolymer34439039.61UniProt (Q8N0S6)
Pfam (PF13092)
Homo sapiens (human)CENP-L,Interphase centromere complex protein 33
6F
(M)
Centromere protein Mpolymer18019761.91UniProt (Q9NSP4)
Pfam (PF11111)
Homo sapiens (human)CENP-M,Interphase centromere complex protein 39,Proliferation-associated nuclear element protein 1
7G
(N)
Centromere protein Npolymer33939609.61UniProt (Q96H22)
Pfam (PF05238)
Homo sapiens (human)CENP-N,Interphase centromere complex protein 32
8H
(O)
Centromere protein Opolymer30033830.61UniProt (Q9BU64)
Pfam (PF09496)
Homo sapiens (human)CENP-O,Interphase centromere complex protein 36
9I
(P)
Centromere protein Ppolymer28833210.91UniProt (Q6IPU0)
Pfam (PF13096)
Homo sapiens (human)CENP-P
10J
(U)
Centromere protein Upolymer41847609.81UniProt (Q71F23)
Pfam (PF13097)
Homo sapiens (human)CENP-U,Centromere protein of 50 kDa,CENP-50,Interphase centromere complex protein 24,KSHV latent nuclear antigen-interacting protein 1,MLF1-interacting protein,Polo-box-interacting protein 1
11K
(Q)
Centromere protein Qpolymer26830648.41UniProt (Q7L2Z9)
Pfam (PF13094)
Homo sapiens (human)CENP-Q
12L
(R)
Centromere protein Rpolymer17720228.31UniProt (Q13352)
Pfam (PF06729)
Homo sapiens (human)CENP-R,Beta-3-endonexin,Integrin beta-3-binding protein,Nuclear receptor-interacting factor 3
13M
(T)
Centromere protein Tpolymer56160502.61UniProt (Q96BT3)
Pfam (PF16171)
Pfam (PF15511)
Homo sapiens (human)CENP-T,Interphase centromere complex protein 22
14N
(W)
Centromere protein Wpolymer8810087.21UniProt (Q5EE01)
Pfam (PF15510)
Homo sapiens (human)CENP-W,Cancer-up-regulated gene 2 protein
15O
(X)
Unknown proteinpolymer151294.61Homo sapiens (human)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains15
Total formula weight544716.8
All*Total formula weight544716.8
*Water molecules are not included.

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PDB entries from 2025-07-16

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