Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7QOO

Structure of the human inner kinetochore CCAN complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000776	cellular_component	kinetochore
C	0019237	molecular_function	centromeric DNA binding
C	0051382	biological_process	kinetochore assembly
H	0000775	cellular_component	chromosome, centromeric region
H	0000776	cellular_component	kinetochore
H	0000939	cellular_component	inner kinetochore
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005730	cellular_component	nucleolus
H	0005829	cellular_component	cytosol
H	0007052	biological_process	mitotic spindle organization
H	0007059	biological_process	chromosome segregation
H	0043515	molecular_function	kinetochore binding
H	0051382	biological_process	kinetochore assembly
H	0051383	biological_process	kinetochore organization
I	0000070	biological_process	mitotic sister chromatid segregation
I	0000775	cellular_component	chromosome, centromeric region
I	0000776	cellular_component	kinetochore
I	0000939	cellular_component	inner kinetochore
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005829	cellular_component	cytosol
I	0007059	biological_process	chromosome segregation
I	0007548	biological_process	sex differentiation
I	0016604	cellular_component	nuclear body
I	0034080	biological_process	CENP-A containing chromatin assembly
I	0034508	biological_process	centromere complex assembly
K	0000070	biological_process	mitotic sister chromatid segregation
K	0000775	cellular_component	chromosome, centromeric region
K	0000776	cellular_component	kinetochore
K	0000939	cellular_component	inner kinetochore
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005829	cellular_component	cytosol
K	0007059	biological_process	chromosome segregation
K	0051382	biological_process	kinetochore assembly
L	0000775	cellular_component	chromosome, centromeric region
L	0000939	cellular_component	inner kinetochore
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005829	cellular_component	cytosol
L	0007059	biological_process	chromosome segregation
M	0000775	cellular_component	chromosome, centromeric region
M	0000776	cellular_component	kinetochore
M	0000939	cellular_component	inner kinetochore
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0007059	biological_process	chromosome segregation
N	0000775	cellular_component	chromosome, centromeric region
N	0000776	cellular_component	kinetochore
N	0000939	cellular_component	inner kinetochore
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005829	cellular_component	cytosol
N	0007059	biological_process	chromosome segregation
N	0034080	biological_process	CENP-A containing chromatin assembly
O	0000775	cellular_component	chromosome, centromeric region
O	0000776	cellular_component	kinetochore
O	0000939	cellular_component	inner kinetochore
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005829	cellular_component	cytosol
O	0007059	biological_process	chromosome segregation
O	0016604	cellular_component	nuclear body
O	0031511	cellular_component	Mis6-Sim4 complex
O	0034508	biological_process	centromere complex assembly
P	0000775	cellular_component	chromosome, centromeric region
P	0000939	cellular_component	inner kinetochore
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005730	cellular_component	nucleolus
P	0005829	cellular_component	cytosol
P	0007059	biological_process	chromosome segregation
P	0034080	biological_process	CENP-A containing chromatin assembly
Q	0000775	cellular_component	chromosome, centromeric region
Q	0000939	cellular_component	inner kinetochore
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0005829	cellular_component	cytosol
Q	0007059	biological_process	chromosome segregation
Q	0015629	cellular_component	actin cytoskeleton
Q	0051310	biological_process	metaphase chromosome alignment
Q	1905342	biological_process	positive regulation of protein localization to kinetochore
R	0000775	cellular_component	chromosome, centromeric region
R	0000776	cellular_component	kinetochore
R	0000939	cellular_component	inner kinetochore
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006915	biological_process	apoptotic process
R	0007059	biological_process	chromosome segregation
R	0007155	biological_process	cell adhesion
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane
R	0034080	biological_process	CENP-A containing chromatin assembly
R	0050679	biological_process	positive regulation of epithelial cell proliferation
R	0051301	biological_process	cell division
R	1904036	biological_process	negative regulation of epithelial cell apoptotic process
T	0000278	biological_process	mitotic cell cycle
T	0000775	cellular_component	chromosome, centromeric region
T	0000776	cellular_component	kinetochore
T	0000939	cellular_component	inner kinetochore
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005694	cellular_component	chromosome
T	0005829	cellular_component	cytosol
T	0007059	biological_process	chromosome segregation
T	0016604	cellular_component	nuclear body
T	0046982	molecular_function	protein heterodimerization activity
T	0051276	biological_process	chromosome organization
T	0051301	biological_process	cell division
T	0051382	biological_process	kinetochore assembly
U	0000775	cellular_component	chromosome, centromeric region
U	0000776	cellular_component	kinetochore
U	0000939	cellular_component	inner kinetochore
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005694	cellular_component	chromosome
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0007059	biological_process	chromosome segregation
U	0034451	cellular_component	centriolar satellite
U	0043009	biological_process	chordate embryonic development
W	0000278	biological_process	mitotic cell cycle
W	0000775	cellular_component	chromosome, centromeric region
W	0000776	cellular_component	kinetochore
W	0000939	cellular_component	inner kinetochore
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005694	cellular_component	chromosome
W	0005730	cellular_component	nucleolus
W	0007059	biological_process	chromosome segregation
W	0016363	cellular_component	nuclear matrix
W	0034080	biological_process	CENP-A containing chromatin assembly
W	0046982	molecular_function	protein heterodimerization activity
W	0051276	biological_process	chromosome organization
W	0051301	biological_process	cell division
W	0051382	biological_process	kinetochore assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	333
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	17
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)