7Q5W
The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (AAA, BBB, CCC, DDD, EEE...) | Tyrosine-protein kinase SYK | polymer | 265 | 29907.0 | 6 | UniProt (P43405) Pfam (PF00017) | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
| 2 | G, H, I, J, K... (GGG, HHH, III, JJJ, KKK...) | TYRO protein tyrosine kinase-binding protein | polymer | 20 | 2490.4 | 6 | UniProt (O43914) | Homo sapiens | DNAX-activation protein 12,Killer-activating receptor-associated protein,KAR-associated protein |
| 3 | M, O, Q, S, U... (AAA, BBB, CCC, DDD, EEE...) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 4 | N, P, T (AAA, BBB, DDD) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | R (CCC) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | V (EEE) | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE | non-polymer | 162.2 | 1 | Chemie (P4G) | |||
| 7 | AA, BA, CA, DA, EA... (DDD, EEE, FFF, GGG, HHH...) | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence modifications
AAA, BBB, CCC, DDD, EEE, FFF: 6 - 269 (UniProt: P43405)
| PDB | External Database | Details |
|---|---|---|
| Ser 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 194384.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1024.4 | |
| All* | Total formula weight | 195408.3 |
