7Q2J
Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Elongin-B | polymer | 104 | 11748.4 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B (B) | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C (C) | von Hippel-Lindau disease tumor suppressor | polymer | 197 | 22503.5 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (Human) | Protein G7,pVHL |
| 4 | D (D) | WD repeat-containing protein 5 | polymer | 312 | 34289.9 | 1 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (Human) | BMP2-induced 3-kb gene protein |
| 5 | E (D) | N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide | non-polymer | 1012.1 | 1 | Chemie (8KH) | |||
| 6 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
B: 17 - 112 (UniProt: Q15369)
C: 54 - 213 (UniProt: P40337)
D: 24 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
| Asn 18 | - | expression tag |
| Thr 19 | - | expression tag |
| Ile 20 | - | expression tag |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| Asn 27 | - | expression tag |
| Thr 28 | - | expression tag |
| Ser 29 | - | expression tag |
| Gly 30 | - | expression tag |
| Ser 31 | - | expression tag |
| Gly 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Gly 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Gly 36 | - | expression tag |
| Arg 37 | - | expression tag |
| Leu 38 | - | expression tag |
| Val 39 | - | expression tag |
| Pro 40 | - | expression tag |
| Arg 41 | - | expression tag |
| Gly 42 | - | expression tag |
| Ser 43 | - | expression tag |
| Met 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Glu 46 | - | expression tag |
| Asn 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Tyr 49 | - | expression tag |
| Phe 50 | - | expression tag |
| Gln 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79516.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 1012.1 | |
| All* | Total formula weight | 80528.5 |
