7Q2J

Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Elongin-B	polymer	104	11748.4	1	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B	Elongin-C	polymer	97	10974.6	1	UniProt (Q15369) Pfam (PF03931) In PDB	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C	von Hippel-Lindau disease tumor suppressor	polymer	197	22503.5	1	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	Homo sapiens (Human)	Protein G7,pVHL
4	D	WD repeat-containing protein 5	polymer	312	34289.9	1	UniProt (P61964) Pfam (PF00400) In PDB	Homo sapiens (Human)	BMP2-induced 3-kb gene protein
5	D	N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide	non-polymer		1012.1	1	Chemie (8KH)
6		water	water		18.0	24	Chemie (HOH)

Sequence modifications

B: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

C: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 17	-	initiating methionine
Asn 18	-	expression tag
Thr 19	-	expression tag
Ile 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
Asn 27	-	expression tag
Thr 28	-	expression tag
Ser 29	-	expression tag
Gly 30	-	expression tag
Ser 31	-	expression tag
Gly 32	-	expression tag
Gly 33	-	expression tag
Gly 34	-	expression tag
Gly 35	-	expression tag
Gly 36	-	expression tag
Arg 37	-	expression tag
Leu 38	-	expression tag
Val 39	-	expression tag
Pro 40	-	expression tag
Arg 41	-	expression tag
Gly 42	-	expression tag
Ser 43	-	expression tag
Met 44	-	expression tag
Ser 45	-	expression tag
Glu 46	-	expression tag
Asn 47	-	expression tag
Leu 48	-	expression tag
Tyr 49	-	expression tag
Phe 50	-	expression tag
Gln 51	-	expression tag
Gly 52	-	expression tag
Ser 53	-	expression tag

D: 24 - 334 (UniProt: P61964)

PDB	External Database	Details
Gly 23	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79516.4
Non-Polymers*	Number of molecules	1
	Total formula weight	1012.1
All*	Total formula weight	80528.5

*Water molecules are not included.