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7Q2J

Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer

Functional Information from GO Data
ChainGOidnamespacecontents
A0006368biological_processtranscription elongation by RNA polymerase II
A0030891cellular_componentVCB complex
A0070449cellular_componentelongin complex
B0006511biological_processubiquitin-dependent protein catabolic process
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000123cellular_componenthistone acetyltransferase complex
D0001501biological_processskeletal system development
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0006094biological_processgluconeogenesis
D0006325biological_processchromatin organization
D0006355biological_processregulation of DNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0035064molecular_functionmethylated histone binding
D0035097cellular_componenthistone methyltransferase complex
D0042393molecular_functionhistone binding
D0042800molecular_functionhistone H3K4 methyltransferase activity
D0044545cellular_componentNSL complex
D0044665cellular_componentMLL1/2 complex
D0044666cellular_componentMLL3/4 complex
D0045722biological_processpositive regulation of gluconeogenesis
D0045815biological_processtranscription initiation-coupled chromatin remodeling
D0045893biological_processpositive regulation of DNA-templated transcription
D0045995biological_processregulation of embryonic development
D0048188cellular_componentSet1C/COMPASS complex
D0051302biological_processregulation of cell division
D0051726biological_processregulation of cell cycle
D0071339cellular_componentMLL1 complex
D0072686cellular_componentmitotic spindle
D0090043biological_processregulation of tubulin deacetylation
D0140672cellular_componentATAC complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
ChainResidueDetails
DLEU102-VAL116
DILE144-VAL158
DILE186-THR200
DILE274-LEU288

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Important for interaction with histone H3
ChainResidueDetails
DASP107
DPHE133
DPHE263
DGLU322

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
DLYS112

site_idSWS_FT_FI3
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DLYS27
DLYS46

223166

PDB entries from 2024-07-31

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