7P9V

Cryo EM structure of System XC-

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	4F2 cell-surface antigen heavy chain	polymer	638	69161.9	1	UniProt (P08195) Pfam (PF16028) Pfam (PF00128)	Homo sapiens (Human)	4F2hc,4F2 heavy chain antigen,Lymphocyte activation antigen 4F2 large subunit,Solute carrier family 3 member 2
2	B (B)	Cystine/glutamate transporter	polymer	509	56466.6	1	UniProt (Q9UPY5) Pfam (PF13520)	Homo sapiens (Human)	Amino acid transport system xc-,Calcium channel blocker resistance protein CCBR1,Solute carrier family 7 member 11,xCT
3	C, D, E, F (C, D, E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)

Sequence modifications

A: 3 - 631 (UniProt: P08195)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag

B: 2 - 501 (UniProt: Q9UPY5)

PDB	External Database	Details
Met -7	-	initiating methionine
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	125628.5
Branched	Number of molecules	4
	Total formula weight	1697.6
All*	Total formula weight	127326.1

*Water molecules are not included.