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7P9V

Cryo EM structure of System XC-

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0003723molecular_functionRNA binding
A0003725molecular_functiondouble-stranded RNA binding
A0005294molecular_functionneutral L-amino acid secondary active transmembrane transporter activity
A0005432molecular_functioncalcium:sodium antiporter activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0005975biological_processcarbohydrate metabolic process
A0006816biological_processcalcium ion transport
A0006865biological_processamino acid transport
A0009925cellular_componentbasal plasma membrane
A0009986cellular_componentcell surface
A0015173molecular_functionaromatic amino acid transmembrane transporter activity
A0015175molecular_functionneutral L-amino acid transmembrane transporter activity
A0015180molecular_functionL-alanine transmembrane transporter activity
A0015190molecular_functionL-leucine transmembrane transporter activity
A0015818biological_processisoleucine transport
A0015820biological_processL-leucine transport
A0015821biological_processmethionine transport
A0015823biological_processphenylalanine transport
A0015824biological_processproline transport
A0015827biological_processtryptophan transport
A0015828biological_processtyrosine transport
A0015829biological_processvaline transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0035725biological_processsodium ion transmembrane transport
A0042470cellular_componentmelanosome
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043330biological_processresponse to exogenous dsRNA
A0044225cellular_componentapical pole of neuron
A0045202cellular_componentsynapse
A0045296molecular_functioncadherin binding
A0046718biological_processsymbiont entry into host cell
A0046982molecular_functionprotein heterodimerization activity
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0070327biological_processthyroid hormone transport
A0140272molecular_functionexogenous protein binding
A1902024biological_processL-histidine transport
A1903801biological_processL-leucine import across plasma membrane
A1904273biological_processL-alanine import across plasma membrane
A1990184cellular_componentamino acid transport complex
B0003333biological_processamino acid transmembrane transport
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006749biological_processglutathione metabolic process
B0006865biological_processamino acid transport
B0006979biological_processresponse to oxidative stress
B0007420biological_processbrain development
B0008542biological_processvisual learning
B0009636biological_processresponse to toxic substance
B0009986cellular_componentcell surface
B0014070biological_processresponse to organic cyclic compound
B0015179molecular_functionL-amino acid transmembrane transporter activity
B0015327molecular_functioncystine:glutamate antiporter activity
B0015804biological_processneutral amino acid transport
B0015811biological_processL-cystine transport
B0015813biological_processL-glutamate transmembrane transport
B0016020cellular_componentmembrane
B0021591biological_processventricular system development
B0021756biological_processstriatum development
B0022857molecular_functiontransmembrane transporter activity
B0030534biological_processadult behavior
B0031526cellular_componentbrush border membrane
B0031528cellular_componentmicrovillus membrane
B0033029biological_processregulation of neutrophil apoptotic process
B0034599biological_processcellular response to oxidative stress
B0034775biological_processglutathione transmembrane transport
B0035094biological_processresponse to nicotine
B0042127biological_processregulation of cell population proliferation
B0042995cellular_componentcell projection
B0045177cellular_componentapical part of cell
B0048021biological_processregulation of melanin biosynthetic process
B0048286biological_processlung alveolus development
B0050804biological_processmodulation of chemical synaptic transmission
B0050807biological_processregulation of synapse organization
B0051223biological_processregulation of protein transport
B0051775biological_processresponse to redox state
B0055085biological_processtransmembrane transport
B0060173biological_processlimb development
B0070306biological_processlens fiber cell differentiation
B0070527biological_processplatelet aggregation
B0071702biological_processorganic substance transport
B0090461biological_processintracellular glutamate homeostasis
B0097449cellular_componentastrocyte projection
B0098712biological_processL-glutamate import across plasma membrane
B0110076biological_processnegative regulation of ferroptosis
B0140206biological_processdipeptide import across plasma membrane
B0140924biological_processL-kynurenine transmembrane transport
B0140926molecular_functionL-kynurenine transmembrane transporter activity
B1900407biological_processregulation of cellular response to oxidative stress
B1901494biological_processregulation of cysteine metabolic process
B1902475biological_processL-alpha-amino acid transmembrane transport
B1903786biological_processregulation of glutathione biosynthetic process
B1904717biological_processregulation of AMPA glutamate receptor clustering
B2000211biological_processregulation of glutamate metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues230
DetailsTRANSMEM: Helical => ECO:0000305|PubMed:15151999
ChainResidueDetails
BVAL44-ILE64
BLEU388-ILE408
BVAL423-LEU443
BTHR450-TRP470
BSER75-LEU95
BLEU131-ILE150
BALA164-LEU179
BLEU194-VAL210
BLEU235-VAL255
BILE266-VAL286
BALA318-VAL338
BPRO365-LEU385

site_idSWS_FT_FI2
Number of Residues80
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:15151999
ChainResidueDetails
BSER65-GLY74
BLEU151-LEU163
BMET211-ARG234
BALA287-LEU317
BASP386-SER387
BTYR444-SER449

site_idSWS_FT_FI3
Number of Residues108
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:15151999
ChainResidueDetails
BSER96-GLY101
BVAL117-GLU130
BASN180-PHE193
BTHR256-THR265
BSER339-THR364
BTYR409-LYS422
BASP471-LEU501

site_idSWS_FT_FI4
Number of Residues14
DetailsINTRAMEM: INTRAMEM => ECO:0000305|PubMed:15151999
ChainResidueDetails
BTHR102-GLU116
ASER135

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:34880232, ECO:0007744|PDB:7P9U
ChainResidueDetails
BARG135
BTYR244

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER26

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN314
ASER409
ASER411
ASER528
ASER532

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
ChainResidueDetails
AASN366

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
ChainResidueDetails
AASN382

site_idSWS_FT_FI10
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
ChainResidueDetails
AASN425

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMH, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
ChainResidueDetails
AASN507

site_idSWS_FT_FI12
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS148

site_idSWS_FT_FI13
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211
ChainResidueDetails
ALYS167

220113

PDB entries from 2024-05-22

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