7P2P

Human Signal Peptidase Complex Paralog A (SPC-A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Signal peptidase complex catalytic subunit SEC11A	polymer	198	22376.1	1	UniProt (P67812) Pfam (PF00717) In PDB	Homo sapiens (Human)	Endopeptidase SP18,Microsomal signal peptidase 18 kDa subunit,SPase 18 kDa subunit,SEC11 homolog A,SEC11-like protein 1,SPC18
2	B	Signal peptidase complex subunit 3	polymer	201	22348.5	1	UniProt (P61009) Pfam (PF04573) In PDB	Homo sapiens (Human)	Microsomal signal peptidase 22/23 kDa subunit,SPC22/23,SPase 22/23 kDa subunit
3	C	Signal peptidase complex subunit 2	polymer	248	27215.2	1	UniProt (Q15005) Pfam (PF06703) In PDB	Homo sapiens (Human)	Microsomal signal peptidase 25 kDa subunit,SPase 25 kDa subunit
4	D	Signal peptidase complex subunit 1	polymer	191	20488.4	1	UniProt (Q9Y6A9) Pfam (PF06645) In PDB	Homo sapiens (Human)	Microsomal signal peptidase 12 kDa subunit,SPase 12 kDa subunit
5	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)

Sequence modifications

A: 1 - 179 (UniProt: P67812)

PDB	External Database	Details
Pro 0	-	expression tag
Gly 180	-	expression tag
Gly 181	-	expression tag
Ser 182	-	expression tag
Pro 183	-	expression tag
Gly 184	-	expression tag
Gly 185	-	expression tag
Ser 186	-	expression tag
Gly 187	-	expression tag
Gly 188	-	expression tag
Gly 189	-	expression tag
Ser 190	-	expression tag
Ala 191	-	expression tag
Glu 192	-	expression tag
Asn 193	-	expression tag
Leu 194	-	expression tag
Tyr 195	-	expression tag
Phe 196	-	expression tag
Gln 197	-	expression tag

B: 1 - 180 (UniProt: P61009)

PDB	External Database	Details
Pro 0	-	expression tag
Gly 181	-	expression tag
Ser 182	-	expression tag
Gly 183	-	expression tag
Glu 184	-	expression tag
Gly 185	-	expression tag
Arg 186	-	expression tag
Gly 187	-	expression tag
Ser 188	-	expression tag
Leu 189	-	expression tag
Leu 190	-	expression tag
Thr 191	-	expression tag
Cys 192	-	expression tag
Gly 193	-	expression tag
Asp 194	-	expression tag
Val 195	-	expression tag
Glu 196	-	expression tag
Glu 197	-	expression tag
Asn 198	-	expression tag
Pro 199	-	expression tag
Gly 200	-	expression tag

C: 1 - 226 (UniProt: Q15005)

PDB	External Database	Details
Gly 227	-	expression tag
Ser 228	-	expression tag
Gly 229	-	expression tag
Gln 230	-	expression tag
Cys 231	-	expression tag
Thr 232	-	expression tag
Asn 233	-	expression tag
Tyr 234	-	expression tag
Ala 235	-	expression tag
Leu 236	-	expression tag
Leu 237	-	expression tag
Lys 238	-	expression tag
Leu 239	-	expression tag
Ala 240	-	expression tag
Gly 241	-	expression tag
Asp 242	-	expression tag
Val 243	-	expression tag
Glu 244	-	expression tag
Ser 245	-	expression tag
Asn 246	-	expression tag
Pro 247	-	expression tag
Gly 248	-	expression tag

D: 1 - 169 (UniProt: Q9Y6A9)

PDB	External Database	Details
Pro 0	-	expression tag
Gly 170	-	expression tag
Ser 171	-	expression tag
Gly 172	-	expression tag
Ala 173	-	expression tag
Thr 174	-	expression tag
Asn 175	-	expression tag
Phe 176	-	expression tag
Ser 177	-	expression tag
Leu 178	-	expression tag
Leu 179	-	expression tag
Lys 180	-	expression tag
Gln 181	-	expression tag
Ala 182	-	expression tag
Gly 183	-	expression tag
Asp 184	-	expression tag
Val 185	-	expression tag
Glu 186	-	expression tag
Glu 187	-	expression tag
Asn 188	-	expression tag
Pro 189	-	expression tag
Gly 190	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	92428.2
Branched	Number of molecules	1
	Total formula weight	910.8
All*	Total formula weight	93339.0

*Water molecules are not included.