7P2P

Human Signal Peptidase Complex Paralog A (SPC-A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005787	cellular_component	signal peptidase complex
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006465	biological_process	signal peptide processing
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0009615	biological_process	response to virus
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005787	cellular_component	signal peptidase complex
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006465	biological_process	signal peptide processing
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane
B	0019082	biological_process	viral protein processing
B	0045047	biological_process	protein targeting to ER
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005787	cellular_component	signal peptidase complex
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006465	biological_process	signal peptide processing
C	0016020	cellular_component	membrane
C	0045047	biological_process	protein targeting to ER
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005787	cellular_component	signal peptidase complex
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006465	biological_process	signal peptide processing
D	0006508	biological_process	proteolysis
D	0016020	cellular_component	membrane
D	0019068	biological_process	virion assembly
D	0019082	biological_process	viral protein processing
D	0045047	biological_process	protein targeting to ER

Functional Information from PROSITE/UniProt

site_id	PS00430
Number of Residues	22
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. pmntvlsranslfa.....................................................................................................FSLSVMAA

Chain	Residue	Details
B	PRO0-ALA21

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site_id	PS00501
Number of Residues	8
Details	SPASE_I_1 Signal peptidases I serine active site. SGSMEPAF

Chain	Residue	Details
A	SER54-PHE61

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site_id	PS00761
Number of Residues	14
Details	SPASE_I_3 Signal peptidases I signature 3. FLTKGDNNavDdrG

Chain	Residue	Details
A	PHE111-GLY124

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	124
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P83362

Chain	Residue	Details
D	MET1-GLY93
D	TYR137-ASN169

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site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
D	ILE94-TRP114
D	VAL116-ILE136

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site_id	SWS_FT_FI3
Number of Residues	1
Details	TOPO_DOM: Lumenal => ECO:0000250|UniProtKB:P83362

Chain	Residue	Details
D	THR115

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:34388369, ECO:0000269|Ref.4, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
C	ALA2
A	HIS96
A	ASP122

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS169
C	LYS191

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