7P2P
Human Signal Peptidase Complex Paralog A (SPC-A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005787 | cellular_component | signal peptidase complex |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006465 | biological_process | signal peptide processing |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0009615 | biological_process | response to virus |
| A | 0016020 | cellular_component | membrane |
| B | 0005515 | molecular_function | protein binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005787 | cellular_component | signal peptidase complex |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006465 | biological_process | signal peptide processing |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| B | 0019082 | biological_process | viral protein processing |
| B | 0045047 | biological_process | protein targeting to ER |
| C | 0005515 | molecular_function | protein binding |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005787 | cellular_component | signal peptidase complex |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0006465 | biological_process | signal peptide processing |
| C | 0016020 | cellular_component | membrane |
| C | 0045047 | biological_process | protein targeting to ER |
| D | 0005515 | molecular_function | protein binding |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005787 | cellular_component | signal peptidase complex |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006465 | biological_process | signal peptide processing |
| D | 0006508 | biological_process | proteolysis |
| D | 0016020 | cellular_component | membrane |
| D | 0019068 | biological_process | virion assembly |
| D | 0019082 | biological_process | viral protein processing |
| D | 0045047 | biological_process | protein targeting to ER |
Functional Information from PROSITE/UniProt
| site_id | PS00430 |
| Number of Residues | 22 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. pmntvlsranslfa.....................................................................................................FSLSVMAA |
| Chain | Residue | Details |
| B | PRO0-ALA21 |
| site_id | PS00501 |
| Number of Residues | 8 |
| Details | SPASE_I_1 Signal peptidases I serine active site. SGSMEPAF |
| Chain | Residue | Details |
| A | SER54-PHE61 |
| site_id | PS00761 |
| Number of Residues | 14 |
| Details | SPASE_I_3 Signal peptidases I signature 3. FLTKGDNNavDdrG |
| Chain | Residue | Details |
| A | PHE111-GLY124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P83362 |
| Chain | Residue | Details |
| D | MET1-GLY93 | |
| D | TYR137-ASN169 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | ILE94-TRP114 | |
| D | VAL116-ILE136 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | TOPO_DOM: Lumenal => ECO:0000250|UniProtKB:P83362 |
| Chain | Residue | Details |
| D | THR115 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:34388369, ECO:0000269|Ref.4, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712 |
| Chain | Residue | Details |
| C | ALA2 | |
| A | HIS96 | |
| A | ASP122 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS169 | |
| C | LYS191 |
