7P0R
Crystal structure of L-Trp/Indoleamine 2,3-dioxygenase (hIDO1) complex with the JK-loop refined in the intermediate conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Indoleamine 2,3-dioxygenase 1 | polymer | 405 | 45300.9 | 4 | UniProt (P14902) Pfam (PF01231) In PDB | Homo sapiens (Human) | IDO-1,Indoleamine-pyrrole 2,3-dioxygenase |
| 2 | D, A, B, C | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | D, A, B, C | GLYCEROL | non-polymer | 92.1 | 16 | Chemie (GOL) | |||
| 4 | C, A | N'-Formylkynurenine | non-polymer | 236.2 | 2 | Chemie (NFK) | |||
| 5 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 6 | D, B | TRYPTOPHAN | non-polymer | 204.2 | 3 | Chemie (TRP) | |||
| 7 | water | water | 18.0 | 497 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 15 - 403 (UniProt: P14902)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ser 2 | - | expression tag |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Ser 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Ala 116 | Lys 116 | engineered mutation |
| Ala 117 | Lys 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 181203.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 5309.5 | |
| All* | Total formula weight | 186513.1 |
