7P0R
Crystal structure of L-Trp/Indoleamine 2,3-dioxygenase (hIDO1) complex with the JK-loop refined in the intermediate conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002376 | biological_process | immune system process |
| A | 0002666 | biological_process | positive regulation of T cell tolerance induction |
| A | 0002678 | biological_process | positive regulation of chronic inflammatory response |
| A | 0002830 | biological_process | positive regulation of type 2 immune response |
| A | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006569 | biological_process | tryptophan catabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007565 | biological_process | female pregnancy |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| A | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
| A | 0020037 | molecular_function | heme binding |
| A | 0030485 | cellular_component | smooth muscle contractile fiber |
| A | 0032421 | cellular_component | stereocilium bundle |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0032693 | biological_process | negative regulation of interleukin-10 production |
| A | 0032735 | biological_process | positive regulation of interleukin-12 production |
| A | 0033555 | biological_process | multicellular organismal response to stress |
| A | 0033754 | molecular_function | indoleamine 2,3-dioxygenase activity |
| A | 0034276 | biological_process | kynurenic acid biosynthetic process |
| A | 0034354 | biological_process | 'de novo' NAD biosynthetic process from tryptophan |
| A | 0036269 | biological_process | swimming behavior |
| A | 0042098 | biological_process | T cell proliferation |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0046006 | biological_process | regulation of activated T cell proliferation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0070233 | biological_process | negative regulation of T cell apoptotic process |
| A | 0070234 | biological_process | positive regulation of T cell apoptotic process |
| B | 0002376 | biological_process | immune system process |
| B | 0002666 | biological_process | positive regulation of T cell tolerance induction |
| B | 0002678 | biological_process | positive regulation of chronic inflammatory response |
| B | 0002830 | biological_process | positive regulation of type 2 immune response |
| B | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006569 | biological_process | tryptophan catabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007565 | biological_process | female pregnancy |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| B | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
| B | 0020037 | molecular_function | heme binding |
| B | 0030485 | cellular_component | smooth muscle contractile fiber |
| B | 0032421 | cellular_component | stereocilium bundle |
| B | 0032496 | biological_process | response to lipopolysaccharide |
| B | 0032693 | biological_process | negative regulation of interleukin-10 production |
| B | 0032735 | biological_process | positive regulation of interleukin-12 production |
| B | 0033555 | biological_process | multicellular organismal response to stress |
| B | 0033754 | molecular_function | indoleamine 2,3-dioxygenase activity |
| B | 0034276 | biological_process | kynurenic acid biosynthetic process |
| B | 0034354 | biological_process | 'de novo' NAD biosynthetic process from tryptophan |
| B | 0036269 | biological_process | swimming behavior |
| B | 0042098 | biological_process | T cell proliferation |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0046006 | biological_process | regulation of activated T cell proliferation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051213 | molecular_function | dioxygenase activity |
| B | 0070233 | biological_process | negative regulation of T cell apoptotic process |
| B | 0070234 | biological_process | positive regulation of T cell apoptotic process |
| C | 0002376 | biological_process | immune system process |
| C | 0002666 | biological_process | positive regulation of T cell tolerance induction |
| C | 0002678 | biological_process | positive regulation of chronic inflammatory response |
| C | 0002830 | biological_process | positive regulation of type 2 immune response |
| C | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006569 | biological_process | tryptophan catabolic process |
| C | 0006954 | biological_process | inflammatory response |
| C | 0007565 | biological_process | female pregnancy |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| C | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
| C | 0020037 | molecular_function | heme binding |
| C | 0030485 | cellular_component | smooth muscle contractile fiber |
| C | 0032421 | cellular_component | stereocilium bundle |
| C | 0032496 | biological_process | response to lipopolysaccharide |
| C | 0032693 | biological_process | negative regulation of interleukin-10 production |
| C | 0032735 | biological_process | positive regulation of interleukin-12 production |
| C | 0033555 | biological_process | multicellular organismal response to stress |
| C | 0033754 | molecular_function | indoleamine 2,3-dioxygenase activity |
| C | 0034276 | biological_process | kynurenic acid biosynthetic process |
| C | 0034354 | biological_process | 'de novo' NAD biosynthetic process from tryptophan |
| C | 0036269 | biological_process | swimming behavior |
| C | 0042098 | biological_process | T cell proliferation |
| C | 0042130 | biological_process | negative regulation of T cell proliferation |
| C | 0043065 | biological_process | positive regulation of apoptotic process |
| C | 0046006 | biological_process | regulation of activated T cell proliferation |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051213 | molecular_function | dioxygenase activity |
| C | 0070233 | biological_process | negative regulation of T cell apoptotic process |
| C | 0070234 | biological_process | positive regulation of T cell apoptotic process |
| D | 0002376 | biological_process | immune system process |
| D | 0002666 | biological_process | positive regulation of T cell tolerance induction |
| D | 0002678 | biological_process | positive regulation of chronic inflammatory response |
| D | 0002830 | biological_process | positive regulation of type 2 immune response |
| D | 0004833 | molecular_function | tryptophan 2,3-dioxygenase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006569 | biological_process | tryptophan catabolic process |
| D | 0006954 | biological_process | inflammatory response |
| D | 0007565 | biological_process | female pregnancy |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| D | 0019441 | biological_process | tryptophan catabolic process to kynurenine |
| D | 0020037 | molecular_function | heme binding |
| D | 0030485 | cellular_component | smooth muscle contractile fiber |
| D | 0032421 | cellular_component | stereocilium bundle |
| D | 0032496 | biological_process | response to lipopolysaccharide |
| D | 0032693 | biological_process | negative regulation of interleukin-10 production |
| D | 0032735 | biological_process | positive regulation of interleukin-12 production |
| D | 0033555 | biological_process | multicellular organismal response to stress |
| D | 0033754 | molecular_function | indoleamine 2,3-dioxygenase activity |
| D | 0034276 | biological_process | kynurenic acid biosynthetic process |
| D | 0034354 | biological_process | 'de novo' NAD biosynthetic process from tryptophan |
| D | 0036269 | biological_process | swimming behavior |
| D | 0042098 | biological_process | T cell proliferation |
| D | 0042130 | biological_process | negative regulation of T cell proliferation |
| D | 0043065 | biological_process | positive regulation of apoptotic process |
| D | 0046006 | biological_process | regulation of activated T cell proliferation |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051213 | molecular_function | dioxygenase activity |
| D | 0070233 | biological_process | negative regulation of T cell apoptotic process |
| D | 0070234 | biological_process | positive regulation of T cell apoptotic process |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: proximal binding residue => ECO:0000269|PubMed:16477023, ECO:0000269|PubMed:25313323, ECO:0007744|PDB:2D0T, ECO:0007744|PDB:2D0U, ECO:0007744|PDB:4PK5, ECO:0007744|PDB:4PK6 |
| Chain | Residue | Details |
| B | HIS346 | |
| C | HIS346 | |
| D | HIS346 | |
| A | HIS346 |
