7OUV

Crystal structure of human filamin C domains 14-15 cardiovascular disease causing mutation S1624L

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 2 of Filamin-C	polymer	205	21507.1	2	UniProt (Q14315) Pfam (PF00630)	Homo sapiens (Human)	FLN-C,FLNc,ABP-280-like protein,ABP-L,Actin-binding-like protein,Filamin-2,Gamma-filamin
2	C, D (A, B)	water	water		18.0	344	Chemie (HOH)

Sequence modifications

A, B: 3 - 205 (UniProt: Q14315)

PDB	External Database	Details
Gly 1	-	expression tag
Pro 2	-	expression tag
Leu 93	Ser 1624	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43014.2
All*	Total formula weight	43014.2

*Water molecules are not included.