7O2W

Structure of the C9orf72-SMCR8 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72	polymer	593	67167.7	1	UniProt (Q12306) UniProt (Q96LT7) Pfam (PF00240) Pfam (PF15019) In PDB	Saccharomyces cerevisiae S288c (Baker's yeast)
2	B	Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein	polymer	1206	134389.4	1	UniProt (Q8TEV9) UniProt (P0AEX9) Pfam (PF11704) Pfam (PF01547) In PDB	Homo sapiens (Human)	Smith-Magenis syndrome chromosomal region candidate gene 8 protein,Smith-Magenis syndrome chromosomal region candidate gene 8 protein,MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP

Sequence modifications

A: -102 - -8 (UniProt: Q12306)

PDB	External Database	Details
Met -111	-	initiating methionine
Ala -110	-	expression tag
His -109	-	expression tag
His -108	-	expression tag
His -107	-	expression tag
His -106	-	expression tag
His -105	-	expression tag
His -104	-	expression tag
Gly -103	-	expression tag
Ser -7	-	linker
Ser -6	-	linker
Gly -5	-	linker
Leu -4	-	linker
Asp -3	-	linker
Ala -2	-	linker
Ala -1	-	linker
Ala 0	-	linker

A: 1 - 481 (UniProt: Q96LT7)
B: 1 - 439 (UniProt: Q8TEV9)

PDB	External Database	Details
Met -44	-	initiating methionine
Asp -43	-	expression tag
Ser -42	-	expression tag
Ala -41	-	expression tag
Trp -40	-	expression tag
Ser -39	-	expression tag
His -38	-	expression tag
Pro -37	-	expression tag
Gln -36	-	expression tag
Phe -35	-	expression tag
Glu -34	-	expression tag
Lys -33	-	expression tag
Gly -32	-	expression tag
Gly -31	-	expression tag
Gly -30	-	expression tag
Ser -29	-	expression tag
Gly -28	-	expression tag
Gly -27	-	expression tag
Gly -26	-	expression tag
Ser -25	-	expression tag
Gly -24	-	expression tag
Gly -23	-	expression tag
Ser -22	-	expression tag
Ala -21	-	expression tag
Trp -20	-	expression tag
Ser -19	-	expression tag
His -18	-	expression tag
Pro -17	-	expression tag
Gln -16	-	expression tag
Phe -15	-	expression tag
Glu -14	-	expression tag
Lys -13	-	expression tag
Ser -12	-	expression tag
Ala -11	-	expression tag
Val -10	-	expression tag
Asp -9	-	expression tag
Leu -8	-	expression tag
Glu -7	-	expression tag
Val -6	-	expression tag
Leu -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Pro -1	-	expression tag
Gly 0	-	expression tag

B: 620 - 937 (UniProt: Q8TEV9)

PDB	External Database	Details
Asp 600	-	linker
Thr 601	-	linker
Gly 602	-	linker
Ser 603	-	linker
Thr 604	-	linker
Gly 605	-	linker
Ser 606	-	linker
Thr 607	-	linker
Ser 608	-	linker
Gly 609	-	linker
Thr 610	-	linker
Leu 611	-	linker
Glu 612	-	linker
Val 613	-	linker
Leu 614	-	linker
Phe 615	-	linker
Gln 616	-	linker
Gly 617	-	linker
Pro 618	-	linker
Gly 619	-	linker
Gly 938	-	linker
Gly 939	-	linker
Ser 940	-	linker
Gly 941	-	linker
Ser 942	-	linker
Glu 943	-	linker
Asn 944	-	linker
Leu 945	-	linker
Tyr 946	-	linker
Phe 947	-	linker
Gln 948	-	linker
Gly 949	-	linker
Gly 950	-	linker
Thr 951	-	linker
Ser 952	-	linker
Ser 953	-	linker
Gly 954	-	linker
Met 955	-	linker

B: 956 - 1321 (UniProt: P0AEX9)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	201557.1
All*	Total formula weight	201557.1

*Water molecules are not included.