7NZE

Crystal structure of HLA-DR4 in complex with a human collagen type II peptide

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (AAA, CCC)	HLA class II histocompatibility antigen, DR alpha chain	polymer	182	21157.9	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	MHC class II antigen DRA
2	B, D (BBB, DDD)	HLA class II histocompatibility antigen DR beta chain	polymer	191	22432.9	2	UniProt (A2BFX2) Pfam (PF00969) Pfam (PF07654)	Homo sapiens (human)	HLA class II histocompatibility antigen,DRB1 beta chain,MHC class II antigen,Major histocompatibility complex,class II,DR beta 1
3	E, F (EEE, FFF)	Collagen alpha-1(II) chain	polymer	15	1473.6	2	UniProt (P02458)	Homo sapiens	Alpha-1 type II collagen
4	G, I, K (AAA, BBB, CCC)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
5	H, J, L, M (AAA, BBB, DDD)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	N, O, P, Q, R... (AAA, BBB, CCC, DDD, EEE...)	water	water		18.0	346	Chemie (HOH)

Sequence modifications

AAA, CCC: 2 - 183 (UniProt: P01903)

PDB	External Database	Details
Arg 46	Glu 71	conflict
Ser 183	Pro 208	conflict

BBB, DDD: 1 - 191 (UniProt: A2BFX2)

PDB	External Database	Details
Lys 71	Arg 100	conflict
Ala 74	Glu 103	conflict
Gly 86	Val 115	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	90129.0
Non-Polymers*	Number of molecules	7
	Total formula weight	1032.0
All*	Total formula weight	91161.0

*Water molecules are not included.