7NWI
Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | L8 | polymer | 244 | 26570.1 | 1 | UniProt (G1TT27) Pfam (PF00181) Pfam (PF03947) | Oryctolagus cuniculus (Rabbit) | |
| 2 | B (B) | uL3 | polymer | 403 | 46108.0 | 1 | UniProt (G1TL06) Pfam (PF00297) | Oryctolagus cuniculus (Rabbit) | |
| 3 | C (C) | 60S ribosomal protein L4 | polymer | 425 | 47727.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 4 | D (D) | 60S ribosomal protein L5 | polymer | 297 | 34481.8 | 1 | UniProt (G1SYJ6) UniProt (by SIFTS) (P19949) | Oryctolagus cuniculus (Rabbit) | |
| 5 | E (E) | 60S ribosomal protein L6 | polymer | 291 | 33055.3 | 1 | UniProt (G1SKF7) Pfam (PF03868) Pfam (PF01159) | Oryctolagus cuniculus (Rabbit) | |
| 6 | F (F) | uL30 | polymer | 249 | 29518.3 | 1 | UniProt (G1SV32) Pfam (PF08079) Pfam (PF00327) | Oryctolagus cuniculus (Rabbit) | |
| 7 | G (G) | 60S ribosomal protein L7a | polymer | 241 | 27480.6 | 1 | UniProt (G1STW0) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 8 | H (H) | L9 | polymer | 190 | 21627.2 | 1 | UniProt (G1SWI6) Pfam (PF00347) | Oryctolagus cuniculus (Rabbit) | |
| 9 | I (I) | 60S ribosomal protein L10 | polymer | 214 | 24643.1 | 1 | UniProt (B7NZQ2) Pfam (PF00252) | Oryctolagus cuniculus (Rabbit) | Ribosomal protein L10 (Predicted) |
| 10 | J (J) | Ribosomal protein L11 | polymer | 181 | 20670.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 11 | K (L) | L13 | polymer | 211 | 24347.7 | 1 | UniProt (G1TKB3) Pfam (PF01294) | Oryctolagus cuniculus (Rabbit) | |
| 12 | L (M) | Ribosomal protein L14 | polymer | 218 | 23870.5 | 1 | UniProt (G1SZ12) Pfam (PF01929) | Oryctolagus cuniculus (Rabbit) | |
| 13 | M (N) | Ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (G1T0C1) Pfam (PF00827) | Oryctolagus cuniculus (Rabbit) | |
| 14 | N (O) | L13a | polymer | 199 | 23248.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 15 | O (P) | L17 | polymer | 153 | 17757.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 16 | P (Q) | Ribosomal_L18e/L15P domain-containing protein | polymer | 188 | 21588.6 | 1 | UniProt (F6QKI9) Pfam (PF17135) UniProt (by SIFTS) (G1TFE0) | Oryctolagus cuniculus (Rabbit) | |
| 17 | Q (R) | 60S ribosomal protein L19 | polymer | 196 | 23535.3 | 1 | UniProt (Q3T0W9) Pfam (PF01280) | Oryctolagus cuniculus (Rabbit) | |
| 18 | R (S) | L18a | polymer | 175 | 20696.4 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 19 | S (T) | eL21 | polymer | 159 | 18478.8 | 1 | UniProt (G1SHQ2) Pfam (PF01157) | Oryctolagus cuniculus (Rabbit) | |
| 20 | T (U) | 60S ribosomal protein L22 | polymer | 128 | 14785.0 | 1 | UniProt (Q4R5I3) Pfam (PF01776) | Oryctolagus cuniculus (Rabbit) | |
| 21 | U (V) | eL14 | polymer | 131 | 13972.4 | 1 | UniProt (G1T6D1) Pfam (PF00238) | Oryctolagus cuniculus (Rabbit) | |
| 22 | V (W) | 60S ribosomal protein L24-like protein | polymer | 134 | 15538.3 | 1 | UniProt (A0A061I3X8) Pfam (PF01246) | Oryctolagus cuniculus (Rabbit) | |
| 23 | W (X) | uL23 | polymer | 156 | 17768.2 | 1 | UniProt (G1SE76) Pfam (PF03939) Pfam (PF00276) | Oryctolagus cuniculus (Rabbit) | |
| 24 | X (Y) | Ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (G1SQH0) Pfam (PF16906) Pfam (PF00467) | Oryctolagus cuniculus (Rabbit) | |
| 25 | Y (Z) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (G1TXF6) Pfam (PF00467) Pfam (PF01777) | Oryctolagus cuniculus (Rabbit) | |
| 26 | Z (a) | uL15 | polymer | 160 | 17831.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 27 | AA (b) | 60S ribosomal protein L29 | polymer | 245 | 26708.7 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 28 | BA (c) | eL30 | polymer | 115 | 12805.1 | 1 | UniProt (G1TDL2) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 29 | CA (d) | eL31 | polymer | 107 | 12635.7 | 1 | UniProt (G1SHG0) Pfam (PF01198) | Oryctolagus cuniculus (Rabbit) | |
| 30 | DA (e) | eL32 | polymer | 128 | 15022.0 | 1 | UniProt (G1TUN8) Pfam (PF01655) | Oryctolagus cuniculus (Rabbit) | |
| 31 | EA (f) | eL33 | polymer | 109 | 12449.6 | 1 | UniProt (G1SF08) Pfam (PF01247) | Oryctolagus cuniculus (Rabbit) | |
| 32 | FA (g) | 60S ribosomal protein L34 | polymer | 126 | 14210.1 | 1 | UniProt (G1U945) Pfam (PF01199) UniProt (by SIFTS) (G1TXG5) | Oryctolagus cuniculus (Rabbit) | |
| 33 | GA (h) | uL29 | polymer | 122 | 14435.4 | 1 | UniProt (G1SIT5) Pfam (PF00831) | Oryctolagus cuniculus (Rabbit) | |
| 34 | HA (i) | 60S ribosomal protein L36 | polymer | 117 | 13546.3 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 35 | IA (j) | Ribosomal protein L37 | polymer | 97 | 11111.0 | 1 | UniProt (U3KPD5) Pfam (PF01907) | Oryctolagus cuniculus (Rabbit) | |
| 36 | JA (k) | L38 | polymer | 69 | 8107.8 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 37 | KA (l) | ribosomal protein eL39 | polymer | 50 | 6295.6 | 1 | UniProt (G1SYU7) Pfam (PF00832) | Oryctolagus cuniculus (Rabbit) | |
| 38 | LA (m) | 60S ribosomal protein L40 | polymer | 128 | 14695.3 | 1 | UniProt (A0A6P4TG29) | Oryctolagus cuniculus (Rabbit) | CEP52,Ubiquitin,Ubiquitin A-52 residue ribosomal protein fusion product 1,Ubiquitin-60S ribosomal protein L40 |
| 39 | MA (n) | 60s ribosomal protein l41 | polymer | 23 | 3213.1 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (Rabbit) | |
| 40 | NA (o) | LOW QUALITY PROTEIN: 60S ribosomal protein L36a | polymer | 142 | 16170.2 | 1 | UniProt (A0A6P5P305) Pfam (PF00935) | Oryctolagus cuniculus (Rabbit) | |
| 41 | OA (p) | ribosomal protein eL43 | polymer | 91 | 10168.2 | 1 | UniProt (G1SY53) Pfam (PF01780) | Oryctolagus cuniculus (Rabbit) | |
| 42 | PA (r) | eL28 | polymer | 137 | 15783.6 | 1 | UniProt (G1U7L1) Pfam (PF01778) | Oryctolagus cuniculus (Rabbit) | |
| 43 | QA (s) | 60S acidic ribosomal protein P0 | polymer | 318 | 34380.5 | 1 | UniProt (G1SPK4) Pfam (PF00466) Pfam (PF17777) Pfam (PF00428) | Oryctolagus cuniculus (Rabbit) | |
| 44 | RA (t) | L12 | polymer | 163 | 17689.5 | 1 | UniProt (G1SMR7) Pfam (PF03946) Pfam (PF00298) | Oryctolagus cuniculus (Rabbit) | |
| 45 | SA (AA) | 40S ribosomal protein SA | polymer | 295 | 32928.0 | 1 | UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122) | Oryctolagus cuniculus (Rabbit) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
| 46 | TA (BB) | 40S ribosomal protein S3a | polymer | 264 | 29942.0 | 1 | UniProt (P97351) Pfam (PF01015) | Oryctolagus cuniculus (Rabbit) | Protein TU-11 |
| 47 | UA (CC) | 40S ribosomal protein S2 | polymer | 259 | 27956.6 | 1 | UniProt (O55214) Pfam (PF00333) Pfam (PF03719) | Oryctolagus cuniculus (Rabbit) | |
| 48 | VA (DD) | 40S ribosomal protein S3 | polymer | 281 | 31146.6 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (Rabbit) | |
| 49 | WA (EE) | S4 | polymer | 262 | 29497.7 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 50 | XA (FF) | Ribosomal protein S5 | polymer | 205 | 23044.7 | 1 | UniProt (G1TFM5) Pfam (PF00177) | Oryctolagus cuniculus (Rabbit) | |
| 51 | YA (GG) | 40S ribosomal protein S6 | polymer | 262 | 30070.4 | 1 | UniProt (A0A6G1APX9) Pfam (PF01092) | Oryctolagus cuniculus (Rabbit) | |
| 52 | ZA (HH) | ribosomal protein eS7 | polymer | 190 | 21716.4 | 1 | UniProt (G1SVB0) | Oryctolagus cuniculus (Rabbit) | |
| 53 | AB (II) | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (Rabbit) | |
| 54 | BB (JJ) | 40S ribosomal protein S9 | polymer | 194 | 22655.6 | 1 | UniProt (A0A1S3APZ1) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (Rabbit) | |
| 55 | CB (KK) | S10_plectin domain-containing protein | polymer | 98 | 11774.0 | 1 | UniProt (G1T168) Pfam (PF03501) | Oryctolagus cuniculus (Rabbit) | |
| 56 | DB (LL) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (Rabbit) | |
| 57 | EB (MM) | 40S ribosomal protein S12 | polymer | 124 | 13766.1 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (Rabbit) | |
| 58 | FB (NN) | ribosomal protein uS15 | polymer | 150 | 17128.2 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (Rabbit) | |
| 59 | GB (OO) | S14 | polymer | 168 | 18134.0 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 60 | HB (PP) | 40S ribosomal protein uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (Rabbit) | |
| 61 | IB (QQ) | Rps16 protein | polymer | 157 | 17585.7 | 1 | UniProt (Q5CZY9) Pfam (PF00380) | Oryctolagus cuniculus (Rabbit) | |
| 62 | JB (RR) | S17 | polymer | 129 | 14969.4 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (Rabbit) | |
| 63 | KB (SS) | ribosomal protein uS13 | polymer | 137 | 16170.8 | 1 | UniProt (G1TPG3) Pfam (PF00416) | Oryctolagus cuniculus (Rabbit) | |
| 64 | LB (TT) | S19 | polymer | 141 | 15683.1 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 65 | MB (UU) | Ribosomal_S10 domain-containing protein | polymer | 104 | 11765.9 | 1 | UniProt (A0A5F9CX53) Pfam (PF00338) | Oryctolagus cuniculus (Rabbit) | |
| 66 | NB (VV) | S21 | polymer | 83 | 9115.4 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 67 | OB (WW) | Ribosomal protein S15a | polymer | 139 | 15778.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 68 | PB (XX) | Ribosomal protein S23 | polymer | 141 | 15626.4 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (Rabbit) | |
| 69 | QB (YY) | 40S ribosomal protein S24 | polymer | 146 | 17007.1 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 70 | RB (ZZ) | 40S ribosomal protein S25 | polymer | 123 | 13582.0 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (Rabbit) | |
| 71 | SB (aa) | 40S ribosomal protein S26 | polymer | 117 | 13147.6 | 1 | UniProt (T0M5X4) | Oryctolagus cuniculus (Rabbit) | |
| 72 | TB (bb) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (Rabbit) | |
| 73 | UB (cc) | 40S ribosomal protein S28 | polymer | 69 | 7776.9 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (Rabbit) | |
| 74 | VB (dd) | ribosomal protein uS14 | polymer | 53 | 6364.4 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (Rabbit) | |
| 75 | WB (ee) | 40S ribosomal protein S30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) | Oryctolagus cuniculus (Rabbit) | |
| 76 | XB (ff) | S27a | polymer | 62 | 7468.9 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 77 | YB (gg) | ribosomal protein RACK1 | polymer | 313 | 34669.1 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (Rabbit) | |
| 78 | ZB (1) | Sec61Beta | polymer | 15 | 1788.0 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 79 | AC (2) | P-Site tRNA | polymer | 76 | 24436.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 80 | BC (5) | 28S ribosomal RNA+BlaS | polymer | 3788 | 1226739.5 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 81 | CC (7) | 5S ribosomal RNA | polymer | 120 | 38691.9 | 1 | GenBank (4CXE_4) | Oryctolagus cuniculus (Rabbit) | |
| 82 | DC (8) | 5.8S ribosomal RNA | polymer | 156 | 50143.6 | 1 | GenBank (4CXE_3) | Oryctolagus cuniculus (Rabbit) | |
| 83 | EC (9) | 18S ribosomal RNA | polymer | 1777 | 573221.6 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 84 | FC (K) | mRNA | polymer | 10 | 3226.0 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 85 | AD, AE, AF, AG, AH... (5, 8, 9, B, P...) | MAGNESIUM ION | non-polymer | 24.3 | 210 | Chemie (MG) | |||
| 86 | KC, MC, OC, PC, QC (g, j, m, o, p) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 87 | BI (5) | BLASTICIDIN S | non-polymer | 422.4 | 1 | Chemie (BLS) |
Sequence modifications
B: 2 - 403 (UniProt: G1TL06)
D: 2 - 297 (UniProt: G1SYJ6)
E: -5 - 284 (UniProt: G1SKF7)
F: 2 - 250 (UniProt: G1SV32)
G: 26 - 266 (UniProt: G1STW0)
L: 1 - 211 (UniProt: G1TKB3)
Q: 1 - 188 (UniProt: F6QKI9)
c: 1 - 115 (UniProt: G1TDL2)
m: 1 - 128 (UniProt: A0A6P4TG29)
CC: 35 - 293 (UniProt: O55214)
FF: 1 - 204 (UniProt: G1TFM5)
II: 2 - 207 (UniProt: G1TJW1)
ZZ: 4 - 125 (UniProt: G1TDB3)
cc: 1 - 69 (UniProt: G1TIB4)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Arg 126 | Lys 133 | conflict |
| Gln 217 | Lys 224 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 175 | Thr 174 | conflict |
| Gly 185 | Asn 184 | conflict |
| Arg 202 | His 201 | conflict |
| Glu 233 | Gly 232 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 191 | Cys 167 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 52 | Ala 52 | conflict |
| Leu 55 | Ile 55 | conflict |
| Arg 74 | His 74 | conflict |
| Arg 190 | His 190 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 77 | Asn 77 | conflict |
| Ile 86 | Val 86 | conflict |
| Ser 106 | Thr 106 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 34 | Ser 34 | conflict |
| Ala 95 | Ser 95 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 54 | Arg 54 | conflict |
| His 74 | Arg 74 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 61 | Ile 27 | conflict |
| Val 73 | Met 39 | conflict |
| Ala 101 | Ser 67 | conflict |
| Ala 119 | Gly 85 | conflict |
| Lys 142 | Glu 108 | conflict |
| Leu 215 | Met 181 | conflict |
| Trp 227 | Arg 193 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| His 5 | Arg 5 | conflict |
| Ile 18 | Leu 18 | conflict |
| Lys 20 | Arg 20 | conflict |
| His 40 | Arg 40 | conflict |
| Thr 42 | Ile 42 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 84 |
| Total formula weight | 3408621.4 | |
| Non-Polymers* | Number of molecules | 216 |
| Total formula weight | 5853.5 | |
| All* | Total formula weight | 3414474.9 |
