7NSG
Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Excitatory amino acid transporter 3 | polymer | 487 | 53252.9 | 3 | UniProt (P43005) Pfam (PF00375) | Homo sapiens (Human) | Excitatory amino-acid carrier 1,Neuronal and epithelial glutamate transporter,Sodium-dependent glutamate/aspartate transporter 3,Solute carrier family 1 member 1 |
| 2 | D, L, T (A, B, C) | (+)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid | non-polymer | 172.1 | 3 | Chemie (UR5) | |||
| 3 | E, M, U (A, B, C) | (-)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid | non-polymer | 172.1 | 3 | Chemie (UR8) | |||
| 4 | F, N, V (A, B, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 3 | Chemie (Y01) | |||
| 5 | AA, G, H, I, J... (C, A, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 15 | Chemie (PC1) |
Sequence modifications
A, B, C: 1 - 480 (UniProt: P43005)
| PDB | External Database | Details |
|---|---|---|
| Arg 42 | Ser 42 | engineered mutation |
| Val 92 | Leu 92 | engineered mutation |
| Ala 481 | - | expression tag |
| Glu 482 | - | expression tag |
| Asn 483 | - | expression tag |
| Leu 484 | - | expression tag |
| Tyr 485 | - | expression tag |
| Phe 486 | - | expression tag |
| Gln 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 159758.6 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 14345.2 | |
| All* | Total formula weight | 174103.8 |
